Results of a surgical resection of pulmonary metastasis from hepatocellular carcinoma: Prognostic impact of the preoperative serum alpha-fetoprotein level

Taro Oba, Tokujiro Yano, Tsukihisa Yoshida, Daigo Kawano, Shuichi Tsukamoto, Fumihiro Shoji, Akinobu Taketomi, Hideki Saitsu, Sadanori Takeo, Yoshihiko Maehara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose Pulmonary metastasis is the most common type of extrahepatic recurrence of hepatocellular carcinoma (HCC). The outcome of pulmonary metastasectomy of HCC has not yet been thoroughly investigated. The outcomes of surgical treatment of pulmonary metastases from HCC were reviewed in order to analyze the postoperative survival and the relevant prognostic factors. Methods This study retrospectively reviewed 20 patients who underwent pulmonary metastasectomy from an HCC between 1990 and 2007 at two institutions. The surgical outcome was evaluated by both the overall survival and cancer-specific survival after pulmonary resection. The association between various clinico-pathological factors and the survival outcome was analyzed. Results The overall survival rate after the initial pulmonary metastasectomy was 46.9% at 5 years, and the cancer-specific 5-year survival rate was 63.2%. One patient died of surgery-related events 19 days after the pulmonary resection. The preoperative AFP (alpha-fetoprotein) level was found to be a significant prognostic factor for both overall and cancer-specific survival for patients undergoing pulmonary metastasectomy. Both the overall and cancerspecific survival rates were significantly worse for the patients with AFP ≥ 500 ng/ml in comparison to those with AFP<500 ng/ml (plt;0.05). No other factors were associated with the survival after pulmonary metastasectomy. Conclusion The serum level of AFP might be a valuable predictor for the outcome of pulmonary metastasectomy required for metastasis of HCC.

Original languageEnglish
Pages (from-to)526-531
Number of pages6
JournalSurgery today
Volume42
Issue number6
DOIs
Publication statusPublished - Jun 1 2012

Fingerprint

alpha-Fetoproteins
Metastasectomy
Hepatocellular Carcinoma
Neoplasm Metastasis
Lung
Serum
Survival
Survival Rate
Neoplasms
Survival Analysis
Recurrence

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Results of a surgical resection of pulmonary metastasis from hepatocellular carcinoma : Prognostic impact of the preoperative serum alpha-fetoprotein level. / Oba, Taro; Yano, Tokujiro; Yoshida, Tsukihisa; Kawano, Daigo; Tsukamoto, Shuichi; Shoji, Fumihiro; Taketomi, Akinobu; Saitsu, Hideki; Takeo, Sadanori; Maehara, Yoshihiko.

In: Surgery today, Vol. 42, No. 6, 01.06.2012, p. 526-531.

Research output: Contribution to journalArticle

Oba, T, Yano, T, Yoshida, T, Kawano, D, Tsukamoto, S, Shoji, F, Taketomi, A, Saitsu, H, Takeo, S & Maehara, Y 2012, 'Results of a surgical resection of pulmonary metastasis from hepatocellular carcinoma: Prognostic impact of the preoperative serum alpha-fetoprotein level', Surgery today, vol. 42, no. 6, pp. 526-531. https://doi.org/10.1007/s00595-011-0090-8
Oba, Taro ; Yano, Tokujiro ; Yoshida, Tsukihisa ; Kawano, Daigo ; Tsukamoto, Shuichi ; Shoji, Fumihiro ; Taketomi, Akinobu ; Saitsu, Hideki ; Takeo, Sadanori ; Maehara, Yoshihiko. / Results of a surgical resection of pulmonary metastasis from hepatocellular carcinoma : Prognostic impact of the preoperative serum alpha-fetoprotein level. In: Surgery today. 2012 ; Vol. 42, No. 6. pp. 526-531.
@article{496bba61959e44d4a5af78d8ddadc5b3,
title = "Results of a surgical resection of pulmonary metastasis from hepatocellular carcinoma: Prognostic impact of the preoperative serum alpha-fetoprotein level",
abstract = "Purpose Pulmonary metastasis is the most common type of extrahepatic recurrence of hepatocellular carcinoma (HCC). The outcome of pulmonary metastasectomy of HCC has not yet been thoroughly investigated. The outcomes of surgical treatment of pulmonary metastases from HCC were reviewed in order to analyze the postoperative survival and the relevant prognostic factors. Methods This study retrospectively reviewed 20 patients who underwent pulmonary metastasectomy from an HCC between 1990 and 2007 at two institutions. The surgical outcome was evaluated by both the overall survival and cancer-specific survival after pulmonary resection. The association between various clinico-pathological factors and the survival outcome was analyzed. Results The overall survival rate after the initial pulmonary metastasectomy was 46.9{\%} at 5 years, and the cancer-specific 5-year survival rate was 63.2{\%}. One patient died of surgery-related events 19 days after the pulmonary resection. The preoperative AFP (alpha-fetoprotein) level was found to be a significant prognostic factor for both overall and cancer-specific survival for patients undergoing pulmonary metastasectomy. Both the overall and cancerspecific survival rates were significantly worse for the patients with AFP ≥ 500 ng/ml in comparison to those with AFP<500 ng/ml (plt;0.05). No other factors were associated with the survival after pulmonary metastasectomy. Conclusion The serum level of AFP might be a valuable predictor for the outcome of pulmonary metastasectomy required for metastasis of HCC.",
author = "Taro Oba and Tokujiro Yano and Tsukihisa Yoshida and Daigo Kawano and Shuichi Tsukamoto and Fumihiro Shoji and Akinobu Taketomi and Hideki Saitsu and Sadanori Takeo and Yoshihiko Maehara",
year = "2012",
month = "6",
day = "1",
doi = "10.1007/s00595-011-0090-8",
language = "English",
volume = "42",
pages = "526--531",
journal = "Surgery Today",
issn = "0941-1291",
publisher = "Springer Japan",
number = "6",

}

TY - JOUR

T1 - Results of a surgical resection of pulmonary metastasis from hepatocellular carcinoma

T2 - Prognostic impact of the preoperative serum alpha-fetoprotein level

AU - Oba, Taro

AU - Yano, Tokujiro

AU - Yoshida, Tsukihisa

AU - Kawano, Daigo

AU - Tsukamoto, Shuichi

AU - Shoji, Fumihiro

AU - Taketomi, Akinobu

AU - Saitsu, Hideki

AU - Takeo, Sadanori

AU - Maehara, Yoshihiko

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Purpose Pulmonary metastasis is the most common type of extrahepatic recurrence of hepatocellular carcinoma (HCC). The outcome of pulmonary metastasectomy of HCC has not yet been thoroughly investigated. The outcomes of surgical treatment of pulmonary metastases from HCC were reviewed in order to analyze the postoperative survival and the relevant prognostic factors. Methods This study retrospectively reviewed 20 patients who underwent pulmonary metastasectomy from an HCC between 1990 and 2007 at two institutions. The surgical outcome was evaluated by both the overall survival and cancer-specific survival after pulmonary resection. The association between various clinico-pathological factors and the survival outcome was analyzed. Results The overall survival rate after the initial pulmonary metastasectomy was 46.9% at 5 years, and the cancer-specific 5-year survival rate was 63.2%. One patient died of surgery-related events 19 days after the pulmonary resection. The preoperative AFP (alpha-fetoprotein) level was found to be a significant prognostic factor for both overall and cancer-specific survival for patients undergoing pulmonary metastasectomy. Both the overall and cancerspecific survival rates were significantly worse for the patients with AFP ≥ 500 ng/ml in comparison to those with AFP<500 ng/ml (plt;0.05). No other factors were associated with the survival after pulmonary metastasectomy. Conclusion The serum level of AFP might be a valuable predictor for the outcome of pulmonary metastasectomy required for metastasis of HCC.

AB - Purpose Pulmonary metastasis is the most common type of extrahepatic recurrence of hepatocellular carcinoma (HCC). The outcome of pulmonary metastasectomy of HCC has not yet been thoroughly investigated. The outcomes of surgical treatment of pulmonary metastases from HCC were reviewed in order to analyze the postoperative survival and the relevant prognostic factors. Methods This study retrospectively reviewed 20 patients who underwent pulmonary metastasectomy from an HCC between 1990 and 2007 at two institutions. The surgical outcome was evaluated by both the overall survival and cancer-specific survival after pulmonary resection. The association between various clinico-pathological factors and the survival outcome was analyzed. Results The overall survival rate after the initial pulmonary metastasectomy was 46.9% at 5 years, and the cancer-specific 5-year survival rate was 63.2%. One patient died of surgery-related events 19 days after the pulmonary resection. The preoperative AFP (alpha-fetoprotein) level was found to be a significant prognostic factor for both overall and cancer-specific survival for patients undergoing pulmonary metastasectomy. Both the overall and cancerspecific survival rates were significantly worse for the patients with AFP ≥ 500 ng/ml in comparison to those with AFP<500 ng/ml (plt;0.05). No other factors were associated with the survival after pulmonary metastasectomy. Conclusion The serum level of AFP might be a valuable predictor for the outcome of pulmonary metastasectomy required for metastasis of HCC.

UR - http://www.scopus.com/inward/record.url?scp=84863985210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863985210&partnerID=8YFLogxK

U2 - 10.1007/s00595-011-0090-8

DO - 10.1007/s00595-011-0090-8

M3 - Article

C2 - 22173647

AN - SCOPUS:84863985210

VL - 42

SP - 526

EP - 531

JO - Surgery Today

JF - Surgery Today

SN - 0941-1291

IS - 6

ER -