Results of combined therapy for maxillary sinus squamous cell carcinoma

Yamada Shoko, Onodera Shu, Yahara Katsuya, Ohguri Takayuki, Kato Fumio, Nomoto Satoshi, Imada Hajime, Nakata Hajime, Terashima Hiromi, Kudoh Koji, Yoshida Masafumi

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Abstract

The results of 54 cases of maxillary sinus squamous cell carcinoma treated between 1980 and 2002 were analyzed retrospectively. The T classification according to the 1997 UICC was as follows: 2 with stage T1, 29 with T3, and 23 with T4. Ten patients (18.5 %) had lymph node metastases at diagnosis. All patients underwent combined therapy including radiotherapy surgery, and regional or systemic chemotherapy. Fifteen patients received hyperfractionated twice-daily radiotherapy (1.2 Gy or 1.5 Gy/fraction), and the remaining 39 patients received a conventional once-daily regimen (1.5-2 Gy/fraction). The 5-year overall survival and 5-year disease-free survival for all patients were 56.0% and 46.7%, respectively. The N classification was the only significant prognostic factor for 5-year disease-free survival by univariate analysis (favoring N=0, p=0.04). There were no significant differences in other prognostic factors including gender, T classification (T1-3 vs. T4), hyperfractionated radiotherapy (yes vs. no), total dose (BED: <69 Gy 10 vs. ≧69 Gy10), and intra-arterial chemotherapy (yes vs. no). Although radiation-induced cataract was observed in 9 patients, no other severe late complications developed.

Original languageEnglish
Pages (from-to)316-321
Number of pages6
JournalNippon Acta Radiologica
Volume63
Issue number6
Publication statusPublished - Jul 25 2003

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Oncology

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