Results of radiation therapy for superficial esophageal cancer using the standard radiotherapy method recommended by the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) Study Group

Kenji Nemoto, Shogo Yamada, Masamichi Nishio, Masahiko Aoki, Ryuji Nakamura, Yasuo Matsumoto, Ryuta Sasamoto, Yoshihiro Saitoh, Makoto Takayama, Norio Mitsuhashi, Kohtaro Gomi, Naoto Kanesaka, Masao Kobayashi, Hiroshi Ohnishi, Shigeru Sasaki, Hiroyasu Tamamura, Michihide Mitsumori, Yasumasa Nishimura, Kayoko Tsujino, Mitsuhiro TakemotoNobue Uchida, Michinori Yamamoto, Yoshiyuki Shioyama, Kohichi Hirakawa, Seiji Ono

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Superficial esophageal cancer (SEC) is defined as esophageal cancer limited to the submucosal layers, including mucosal cancer and submucosal cancer, and is squamous cell carcinoma in most patients. In 2000, the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) Study Group for SEC published a consensus guideline of standard radiotherapy methods. In this study, the interim treatment outcomes of SEC patients, who had received radiation therapy following the standard radiotherapy methods, were investigated. Patients and Methods: From 2000 to 2003, a total of 141 SEC patients were treated in 24 institutions in Japan. Results: The 1-, 2- and 3-year survival rates were 95%, 90% and 90%, respectively, for patients with mucosal cancer and 90%, 81% and 70%, respectively, for patients with submucosal cancer. The overall survival was better in patients who had undergone chemotherapy than in patients who had received radiation therapy alone, though the difference was not statistically significant. The clinical target volume (CTV) did not influence overall survival and intracavitary irradiation did not influence the local control rate in either patients with mucosal or submucosal cancer. Radiation-induced esophageal ulcer was not observed in this series. Conclusion: The standard radiotherapy methods are safe and effective for treating SEC. However, the usefulness of chemotherapy and intracavitary irradiation and the optimal setting of the CTV should be clarified by future randomized trials.

Original languageEnglish
Pages (from-to)1507-1512
Number of pages6
JournalAnticancer research
Volume26
Issue number2 B
Publication statusPublished - Mar 1 2006
Externally publishedYes

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Radiation Oncology
Esophageal Neoplasms
Radiotherapy
Neoplasms
Drug Therapy
Survival
Ulcer
Squamous Cell Carcinoma
Japan
Survival Rate
Guidelines
Radiation

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Results of radiation therapy for superficial esophageal cancer using the standard radiotherapy method recommended by the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) Study Group. / Nemoto, Kenji; Yamada, Shogo; Nishio, Masamichi; Aoki, Masahiko; Nakamura, Ryuji; Matsumoto, Yasuo; Sasamoto, Ryuta; Saitoh, Yoshihiro; Takayama, Makoto; Mitsuhashi, Norio; Gomi, Kohtaro; Kanesaka, Naoto; Kobayashi, Masao; Ohnishi, Hiroshi; Sasaki, Shigeru; Tamamura, Hiroyasu; Mitsumori, Michihide; Nishimura, Yasumasa; Tsujino, Kayoko; Takemoto, Mitsuhiro; Uchida, Nobue; Yamamoto, Michinori; Shioyama, Yoshiyuki; Hirakawa, Kohichi; Ono, Seiji.

In: Anticancer research, Vol. 26, No. 2 B, 01.03.2006, p. 1507-1512.

Research output: Contribution to journalArticle

Nemoto, K, Yamada, S, Nishio, M, Aoki, M, Nakamura, R, Matsumoto, Y, Sasamoto, R, Saitoh, Y, Takayama, M, Mitsuhashi, N, Gomi, K, Kanesaka, N, Kobayashi, M, Ohnishi, H, Sasaki, S, Tamamura, H, Mitsumori, M, Nishimura, Y, Tsujino, K, Takemoto, M, Uchida, N, Yamamoto, M, Shioyama, Y, Hirakawa, K & Ono, S 2006, 'Results of radiation therapy for superficial esophageal cancer using the standard radiotherapy method recommended by the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) Study Group', Anticancer research, vol. 26, no. 2 B, pp. 1507-1512.
Nemoto, Kenji ; Yamada, Shogo ; Nishio, Masamichi ; Aoki, Masahiko ; Nakamura, Ryuji ; Matsumoto, Yasuo ; Sasamoto, Ryuta ; Saitoh, Yoshihiro ; Takayama, Makoto ; Mitsuhashi, Norio ; Gomi, Kohtaro ; Kanesaka, Naoto ; Kobayashi, Masao ; Ohnishi, Hiroshi ; Sasaki, Shigeru ; Tamamura, Hiroyasu ; Mitsumori, Michihide ; Nishimura, Yasumasa ; Tsujino, Kayoko ; Takemoto, Mitsuhiro ; Uchida, Nobue ; Yamamoto, Michinori ; Shioyama, Yoshiyuki ; Hirakawa, Kohichi ; Ono, Seiji. / Results of radiation therapy for superficial esophageal cancer using the standard radiotherapy method recommended by the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) Study Group. In: Anticancer research. 2006 ; Vol. 26, No. 2 B. pp. 1507-1512.
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abstract = "Background: Superficial esophageal cancer (SEC) is defined as esophageal cancer limited to the submucosal layers, including mucosal cancer and submucosal cancer, and is squamous cell carcinoma in most patients. In 2000, the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) Study Group for SEC published a consensus guideline of standard radiotherapy methods. In this study, the interim treatment outcomes of SEC patients, who had received radiation therapy following the standard radiotherapy methods, were investigated. Patients and Methods: From 2000 to 2003, a total of 141 SEC patients were treated in 24 institutions in Japan. Results: The 1-, 2- and 3-year survival rates were 95{\%}, 90{\%} and 90{\%}, respectively, for patients with mucosal cancer and 90{\%}, 81{\%} and 70{\%}, respectively, for patients with submucosal cancer. The overall survival was better in patients who had undergone chemotherapy than in patients who had received radiation therapy alone, though the difference was not statistically significant. The clinical target volume (CTV) did not influence overall survival and intracavitary irradiation did not influence the local control rate in either patients with mucosal or submucosal cancer. Radiation-induced esophageal ulcer was not observed in this series. Conclusion: The standard radiotherapy methods are safe and effective for treating SEC. However, the usefulness of chemotherapy and intracavitary irradiation and the optimal setting of the CTV should be clarified by future randomized trials.",
author = "Kenji Nemoto and Shogo Yamada and Masamichi Nishio and Masahiko Aoki and Ryuji Nakamura and Yasuo Matsumoto and Ryuta Sasamoto and Yoshihiro Saitoh and Makoto Takayama and Norio Mitsuhashi and Kohtaro Gomi and Naoto Kanesaka and Masao Kobayashi and Hiroshi Ohnishi and Shigeru Sasaki and Hiroyasu Tamamura and Michihide Mitsumori and Yasumasa Nishimura and Kayoko Tsujino and Mitsuhiro Takemoto and Nobue Uchida and Michinori Yamamoto and Yoshiyuki Shioyama and Kohichi Hirakawa and Seiji Ono",
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T1 - Results of radiation therapy for superficial esophageal cancer using the standard radiotherapy method recommended by the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) Study Group

AU - Nemoto, Kenji

AU - Yamada, Shogo

AU - Nishio, Masamichi

AU - Aoki, Masahiko

AU - Nakamura, Ryuji

AU - Matsumoto, Yasuo

AU - Sasamoto, Ryuta

AU - Saitoh, Yoshihiro

AU - Takayama, Makoto

AU - Mitsuhashi, Norio

AU - Gomi, Kohtaro

AU - Kanesaka, Naoto

AU - Kobayashi, Masao

AU - Ohnishi, Hiroshi

AU - Sasaki, Shigeru

AU - Tamamura, Hiroyasu

AU - Mitsumori, Michihide

AU - Nishimura, Yasumasa

AU - Tsujino, Kayoko

AU - Takemoto, Mitsuhiro

AU - Uchida, Nobue

AU - Yamamoto, Michinori

AU - Shioyama, Yoshiyuki

AU - Hirakawa, Kohichi

AU - Ono, Seiji

PY - 2006/3/1

Y1 - 2006/3/1

N2 - Background: Superficial esophageal cancer (SEC) is defined as esophageal cancer limited to the submucosal layers, including mucosal cancer and submucosal cancer, and is squamous cell carcinoma in most patients. In 2000, the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) Study Group for SEC published a consensus guideline of standard radiotherapy methods. In this study, the interim treatment outcomes of SEC patients, who had received radiation therapy following the standard radiotherapy methods, were investigated. Patients and Methods: From 2000 to 2003, a total of 141 SEC patients were treated in 24 institutions in Japan. Results: The 1-, 2- and 3-year survival rates were 95%, 90% and 90%, respectively, for patients with mucosal cancer and 90%, 81% and 70%, respectively, for patients with submucosal cancer. The overall survival was better in patients who had undergone chemotherapy than in patients who had received radiation therapy alone, though the difference was not statistically significant. The clinical target volume (CTV) did not influence overall survival and intracavitary irradiation did not influence the local control rate in either patients with mucosal or submucosal cancer. Radiation-induced esophageal ulcer was not observed in this series. Conclusion: The standard radiotherapy methods are safe and effective for treating SEC. However, the usefulness of chemotherapy and intracavitary irradiation and the optimal setting of the CTV should be clarified by future randomized trials.

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