Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells

Toshihiro Ichiki, Ryohei Miyazaki, Aya Kamiharaguchi, Toru Hashimoto, Hirohide Matsuura, Shiro Kitamoto, Tomotake Tokunou, Kenji Sunagawa

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Abstract

Resveratrol (3,5,4'-trihydroxystilbene), a polyphenol abundant in red wine, is known to extend the life span of diverse species. On the contrary, it was reported that angiotensin (Ang) II enhances senescence of vascular smooth muscle cells (VSMCs). We, therefore, examined whether resveratrol attenuates Ang II-induced senescence of VSMC. Senescence-associated β-galactosidase (SA β-gal) assay showed that Ang II induced senescence of VSMC. The Ang II-induced senescence was inhibited by losartan, an Ang II type 1 receptor (AT1R) antagonist but not by PD123319, Ang II type 2 receptor antagonist, indicating that AT1R is responsible for the induction of senescence. Resveratrol suppressed Ang II-induced senescence of VSMC in a dose-dependent manner. In addition, resveratrol suppressed Ang II-induced induction of p53 and its downstream target gene p21, both of which play an important role in the induction of senescence. Resveratrol suppressed senescence of VSMC possibly through inhibition of AT1R-dependent induction of p53/p21. Suppression of p53 induction may be involved in the longevity by resveratrol.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalRegulatory Peptides
Volume177
Issue number1-3
DOIs
Publication statusPublished - Aug 20 2012

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Ichiki, T., Miyazaki, R., Kamiharaguchi, A., Hashimoto, T., Matsuura, H., Kitamoto, S., ... Sunagawa, K. (2012). Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells. Regulatory Peptides, 177(1-3), 35-39. https://doi.org/10.1016/j.regpep.2012.04.005