Retrospective study of selective submandibular neck dissection versus radical neck dissection for N0 or N1 necks in level i patients with oral squamous cell carcinoma

Yuta Yanai, Tsuyoshi Sugiura, Ikumi Imajyo, Naoya Yoshihama, Naonari Akimoto, Yosuke Kobayashi, Kohei Hayashi, Takahiro Fujinaga, Kanemitsu Shirasuna, Yasuharu Takenoshita, Yoshihide Mori

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Abstract

Objective. To evaluate the efficacy of selective submandibular neck dissection (SMND) in patients with oral squamous cell carcinoma (OSCC) with or without nodal metastasis. Patients. From a total of 384 patients with untreated OSCC who underwent radical excision, we identified 229 with clinically N0 necks and 68 with clinically N1 necks in level I. Main Outcome Measures. The Kaplan-Meier 5-year regional control and 5-year disease specific survival (DSS) were compared for SMND, radical neck dissection (RND), and modified radical neck dissection (MRND). Results. In clinically node-negative necks, the regional control rates were 85.2% with SMND and 83.3% with MRND (P=0.89), and 5-year DSS rates were 86.5% and 87.0%, respectively, (P=0.94). In clinically N1 necks, the regional control rates were 81.3% with SMND and 83.0% with RND (P=0.72), and the DSS rates were 81.3% and 80.0%, respectively, (P=0.94). Type of neck dissection was not significantly associated with regional control or DSS on either univariate or multivariate analysis using Cox's proportional hazard model. Conclusions. SMND can be effectively applied in elective and therapeutic management to patients with OSCC that are clinically assessed as N0 or N1 to level I of the neck.

Original languageEnglish
Article number634183
JournalJournal of Oncology
DOIs
Publication statusPublished - Jun 20 2012

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Neck Dissection
Squamous Cell Carcinoma
Neck
Retrospective Studies
Survival Rate
Survival
Proportional Hazards Models
Multivariate Analysis
Outcome Assessment (Health Care)
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Oncology

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Retrospective study of selective submandibular neck dissection versus radical neck dissection for N0 or N1 necks in level i patients with oral squamous cell carcinoma. / Yanai, Yuta; Sugiura, Tsuyoshi; Imajyo, Ikumi; Yoshihama, Naoya; Akimoto, Naonari; Kobayashi, Yosuke; Hayashi, Kohei; Fujinaga, Takahiro; Shirasuna, Kanemitsu; Takenoshita, Yasuharu; Mori, Yoshihide.

In: Journal of Oncology, 20.06.2012.

Research output: Contribution to journalArticle

Yanai, Yuta ; Sugiura, Tsuyoshi ; Imajyo, Ikumi ; Yoshihama, Naoya ; Akimoto, Naonari ; Kobayashi, Yosuke ; Hayashi, Kohei ; Fujinaga, Takahiro ; Shirasuna, Kanemitsu ; Takenoshita, Yasuharu ; Mori, Yoshihide. / Retrospective study of selective submandibular neck dissection versus radical neck dissection for N0 or N1 necks in level i patients with oral squamous cell carcinoma. In: Journal of Oncology. 2012.
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abstract = "Objective. To evaluate the efficacy of selective submandibular neck dissection (SMND) in patients with oral squamous cell carcinoma (OSCC) with or without nodal metastasis. Patients. From a total of 384 patients with untreated OSCC who underwent radical excision, we identified 229 with clinically N0 necks and 68 with clinically N1 necks in level I. Main Outcome Measures. The Kaplan-Meier 5-year regional control and 5-year disease specific survival (DSS) were compared for SMND, radical neck dissection (RND), and modified radical neck dissection (MRND). Results. In clinically node-negative necks, the regional control rates were 85.2{\%} with SMND and 83.3{\%} with MRND (P=0.89), and 5-year DSS rates were 86.5{\%} and 87.0{\%}, respectively, (P=0.94). In clinically N1 necks, the regional control rates were 81.3{\%} with SMND and 83.0{\%} with RND (P=0.72), and the DSS rates were 81.3{\%} and 80.0{\%}, respectively, (P=0.94). Type of neck dissection was not significantly associated with regional control or DSS on either univariate or multivariate analysis using Cox's proportional hazard model. Conclusions. SMND can be effectively applied in elective and therapeutic management to patients with OSCC that are clinically assessed as N0 or N1 to level I of the neck.",
author = "Yuta Yanai and Tsuyoshi Sugiura and Ikumi Imajyo and Naoya Yoshihama and Naonari Akimoto and Yosuke Kobayashi and Kohei Hayashi and Takahiro Fujinaga and Kanemitsu Shirasuna and Yasuharu Takenoshita and Yoshihide Mori",
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AU - Yoshihama, Naoya

AU - Akimoto, Naonari

AU - Kobayashi, Yosuke

AU - Hayashi, Kohei

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AU - Shirasuna, Kanemitsu

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N2 - Objective. To evaluate the efficacy of selective submandibular neck dissection (SMND) in patients with oral squamous cell carcinoma (OSCC) with or without nodal metastasis. Patients. From a total of 384 patients with untreated OSCC who underwent radical excision, we identified 229 with clinically N0 necks and 68 with clinically N1 necks in level I. Main Outcome Measures. The Kaplan-Meier 5-year regional control and 5-year disease specific survival (DSS) were compared for SMND, radical neck dissection (RND), and modified radical neck dissection (MRND). Results. In clinically node-negative necks, the regional control rates were 85.2% with SMND and 83.3% with MRND (P=0.89), and 5-year DSS rates were 86.5% and 87.0%, respectively, (P=0.94). In clinically N1 necks, the regional control rates were 81.3% with SMND and 83.0% with RND (P=0.72), and the DSS rates were 81.3% and 80.0%, respectively, (P=0.94). Type of neck dissection was not significantly associated with regional control or DSS on either univariate or multivariate analysis using Cox's proportional hazard model. Conclusions. SMND can be effectively applied in elective and therapeutic management to patients with OSCC that are clinically assessed as N0 or N1 to level I of the neck.

AB - Objective. To evaluate the efficacy of selective submandibular neck dissection (SMND) in patients with oral squamous cell carcinoma (OSCC) with or without nodal metastasis. Patients. From a total of 384 patients with untreated OSCC who underwent radical excision, we identified 229 with clinically N0 necks and 68 with clinically N1 necks in level I. Main Outcome Measures. The Kaplan-Meier 5-year regional control and 5-year disease specific survival (DSS) were compared for SMND, radical neck dissection (RND), and modified radical neck dissection (MRND). Results. In clinically node-negative necks, the regional control rates were 85.2% with SMND and 83.3% with MRND (P=0.89), and 5-year DSS rates were 86.5% and 87.0%, respectively, (P=0.94). In clinically N1 necks, the regional control rates were 81.3% with SMND and 83.0% with RND (P=0.72), and the DSS rates were 81.3% and 80.0%, respectively, (P=0.94). Type of neck dissection was not significantly associated with regional control or DSS on either univariate or multivariate analysis using Cox's proportional hazard model. Conclusions. SMND can be effectively applied in elective and therapeutic management to patients with OSCC that are clinically assessed as N0 or N1 to level I of the neck.

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