Reversal of diffuse patchy pattern in lung perfusion scan in a case of severe pulmonary arterial hypertension

Yoshihiko Kodama, Kotaro Abe, Kazuya Hosokawa, kisho ohtani, Michinobu Nagao, Yoshitaka Hirooka, Kenji Sunagawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A diffuse patchy pattern in the perfusion scan of the lung is a hallmark of severe pulmonary arterial hypertension (PAH). However, the mechanisms of this unique pattern remain uncertain. We here present the case of a 19-year-old woman with severe PAH who demonstrated reversal of the diffuse patchy pattern with improvement of pulmonary blood flow within a month after upfront triple combination therapy. Our case is a first report showing reversibility of diffuse patchy pattern by a short-term treatment in severe PAH. These findings suggest the possibility that the mechanisms underlying the diffuse patchy pattern may involve reversible vasoconstriction in addition to remodeling of small pulmonary arteries.

Original languageEnglish
Pages (from-to)451-452
Number of pages2
JournalHeart and Lung: Journal of Acute and Critical Care
Volume44
Issue number5
DOIs
Publication statusPublished - Sep 1 2015

Fingerprint

Pulmonary Hypertension
Perfusion
Lung
Vasoconstriction
Pulmonary Artery
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Reversal of diffuse patchy pattern in lung perfusion scan in a case of severe pulmonary arterial hypertension. / Kodama, Yoshihiko; Abe, Kotaro; Hosokawa, Kazuya; ohtani, kisho; Nagao, Michinobu; Hirooka, Yoshitaka; Sunagawa, Kenji.

In: Heart and Lung: Journal of Acute and Critical Care, Vol. 44, No. 5, 01.09.2015, p. 451-452.

Research output: Contribution to journalArticle

Kodama, Yoshihiko ; Abe, Kotaro ; Hosokawa, Kazuya ; ohtani, kisho ; Nagao, Michinobu ; Hirooka, Yoshitaka ; Sunagawa, Kenji. / Reversal of diffuse patchy pattern in lung perfusion scan in a case of severe pulmonary arterial hypertension. In: Heart and Lung: Journal of Acute and Critical Care. 2015 ; Vol. 44, No. 5. pp. 451-452.
@article{042e87b67f224db0b30c845a40b1f099,
title = "Reversal of diffuse patchy pattern in lung perfusion scan in a case of severe pulmonary arterial hypertension",
abstract = "A diffuse patchy pattern in the perfusion scan of the lung is a hallmark of severe pulmonary arterial hypertension (PAH). However, the mechanisms of this unique pattern remain uncertain. We here present the case of a 19-year-old woman with severe PAH who demonstrated reversal of the diffuse patchy pattern with improvement of pulmonary blood flow within a month after upfront triple combination therapy. Our case is a first report showing reversibility of diffuse patchy pattern by a short-term treatment in severe PAH. These findings suggest the possibility that the mechanisms underlying the diffuse patchy pattern may involve reversible vasoconstriction in addition to remodeling of small pulmonary arteries.",
author = "Yoshihiko Kodama and Kotaro Abe and Kazuya Hosokawa and kisho ohtani and Michinobu Nagao and Yoshitaka Hirooka and Kenji Sunagawa",
year = "2015",
month = "9",
day = "1",
doi = "10.1016/j.hrtlng.2015.06.005",
language = "English",
volume = "44",
pages = "451--452",
journal = "Heart and Lung: Journal of Acute and Critical Care",
issn = "0147-9563",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Reversal of diffuse patchy pattern in lung perfusion scan in a case of severe pulmonary arterial hypertension

AU - Kodama, Yoshihiko

AU - Abe, Kotaro

AU - Hosokawa, Kazuya

AU - ohtani, kisho

AU - Nagao, Michinobu

AU - Hirooka, Yoshitaka

AU - Sunagawa, Kenji

PY - 2015/9/1

Y1 - 2015/9/1

N2 - A diffuse patchy pattern in the perfusion scan of the lung is a hallmark of severe pulmonary arterial hypertension (PAH). However, the mechanisms of this unique pattern remain uncertain. We here present the case of a 19-year-old woman with severe PAH who demonstrated reversal of the diffuse patchy pattern with improvement of pulmonary blood flow within a month after upfront triple combination therapy. Our case is a first report showing reversibility of diffuse patchy pattern by a short-term treatment in severe PAH. These findings suggest the possibility that the mechanisms underlying the diffuse patchy pattern may involve reversible vasoconstriction in addition to remodeling of small pulmonary arteries.

AB - A diffuse patchy pattern in the perfusion scan of the lung is a hallmark of severe pulmonary arterial hypertension (PAH). However, the mechanisms of this unique pattern remain uncertain. We here present the case of a 19-year-old woman with severe PAH who demonstrated reversal of the diffuse patchy pattern with improvement of pulmonary blood flow within a month after upfront triple combination therapy. Our case is a first report showing reversibility of diffuse patchy pattern by a short-term treatment in severe PAH. These findings suggest the possibility that the mechanisms underlying the diffuse patchy pattern may involve reversible vasoconstriction in addition to remodeling of small pulmonary arteries.

UR - http://www.scopus.com/inward/record.url?scp=84940587844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940587844&partnerID=8YFLogxK

U2 - 10.1016/j.hrtlng.2015.06.005

DO - 10.1016/j.hrtlng.2015.06.005

M3 - Article

C2 - 26138776

AN - SCOPUS:84940587844

VL - 44

SP - 451

EP - 452

JO - Heart and Lung: Journal of Acute and Critical Care

JF - Heart and Lung: Journal of Acute and Critical Care

SN - 0147-9563

IS - 5

ER -