[Reversed halo sign in organizing pneumonia secondary to Sjögren syndrome].

Satoshi Anai, Hiroyuki Kumazoe, Kentarou Wakamatsu, Nobuhiko Nagata, Yoichi Nakanishi, Akira Kajiki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report a case of a 41-year-old woman admitted to our hospital for dyspnea on exertion and nonproductive cough. High-resolution computed tomography (HRCT) revealed central ground-glass opacities surrounded by ring-shaped areas of consolidation (reversed halo sign), predominantly in the lower lobes. Bronchoalveolar lavage fluid revealed an increase of the total number of cells (35 x 10(4)/ml), including elevated lymphocyte level (69%) and decreased CD4/CD8 ratio (0.45). Histopathological examination by transbronchial lung biopsy showed polypoid masses of granulation tissue filling the lumens of a respiratory bronchiole and alveolar ducts, consistent with organizing pneumonia. After admission the patient complained of dry eyes and dry mouth. The serum anti-SS-A antibody level was also elevated (65.0 U/ml). Labial salivary gland biopsy specimens revealed focal lymphocytic infiltration of more than 50 per 4 mm(2). There were no findings of rheumatoid arthritis or other collagen diseases. We diagnosed primary Sjögren syndrome with secondary organizing pneumonia with a reversed halo sign. She was treated with prednisolone (0.5 mg/kg body weight, 35 mg/day). After treatment, the chest CT showed improvement through consolidation.

Original languageEnglish
Pages (from-to)707-712
Number of pages6
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume49
Issue number9
Publication statusPublished - Jan 1 2011

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Pneumonia
Bronchioles
Biopsy
Collagen Diseases
CD4-CD8 Ratio
Granulation Tissue
Patient Admission
Bronchoalveolar Lavage Fluid
Lip
Prednisolone
Salivary Glands
Cough
Dyspnea
Glass
Mouth
Rheumatoid Arthritis
Thorax
Cell Count
Tomography
Body Weight

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Anai, S., Kumazoe, H., Wakamatsu, K., Nagata, N., Nakanishi, Y., & Kajiki, A. (2011). [Reversed halo sign in organizing pneumonia secondary to Sjögren syndrome]. Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 49(9), 707-712.

[Reversed halo sign in organizing pneumonia secondary to Sjögren syndrome]. / Anai, Satoshi; Kumazoe, Hiroyuki; Wakamatsu, Kentarou; Nagata, Nobuhiko; Nakanishi, Yoichi; Kajiki, Akira.

In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, Vol. 49, No. 9, 01.01.2011, p. 707-712.

Research output: Contribution to journalArticle

Anai, S, Kumazoe, H, Wakamatsu, K, Nagata, N, Nakanishi, Y & Kajiki, A 2011, '[Reversed halo sign in organizing pneumonia secondary to Sjögren syndrome].', Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, vol. 49, no. 9, pp. 707-712.
Anai, Satoshi ; Kumazoe, Hiroyuki ; Wakamatsu, Kentarou ; Nagata, Nobuhiko ; Nakanishi, Yoichi ; Kajiki, Akira. / [Reversed halo sign in organizing pneumonia secondary to Sjögren syndrome]. In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2011 ; Vol. 49, No. 9. pp. 707-712.
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