Reversible and selective antagonism by suramin of ATP-activated inward current in PC12 phaeochromocytoma cells

K. Nakazawa, K. Fujimori, A. Takanaka, K. Inoue

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41 Citations (Scopus)

Abstract

1. The effects of suramin on an adenosine 5'-triphosphate (ATP)-activated inward current were investigated in PC12 phaeochromocytoma cells with whole-cell voltage-clamp techniques. 2. Suramin (30 to 300 μM) inhibited the ATP-activated current in a dose-dependent manner. The inhibitory effects were reversible and competitive. 3. Suramin also suppressed the current activated by adenosine 5'-O-(3-thiotriphosphate) but did not affect the current activated by nicotine. Suramin did not affect the suppression of a K current induced by methacholine. 4. The results suggest that suramin antagonizes the ATP-receptor-operated membrane current reversibly and selectively.

Original languageEnglish
Pages (from-to)224-226
Number of pages3
JournalBritish Journal of Pharmacology
Volume101
Issue number1
DOIs
Publication statusPublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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