Reversible electrical breakdown of bilayer lipid membranes with a ramped voltage and the quantitative analysis based on a transient aqueous pore model

Junya Suehiro, H. Fujinobu, M. Hara

Research output: Contribution to journalArticle

Abstract

Reversible electrical breakdown of bilayer lipid membranes is observed by using the voltage-clamp method with ramped voltage waveforms. It is shown experimentally that the critical transmembrane voltage at which membrane conductance drastically increases depends on the ramp rate. The pore growing process is discussed quantitatively based on a transient pore model of the breakdown phenomena. The comparison between the experimental results and theoretical prediction shows that the model can describe the time course of the pore development and resultant increase in the membrane conductance. Effects of the voltage rising rate on the electroporation and the membrane conductance increase are discussed by using the transient pore model. (from Authors)

Original languageEnglish
Pages (from-to)263-277
Number of pages15
JournalMemoirs - Kyushu University, Faculty of Engineering
Volume54
Issue number4
Publication statusPublished - Jan 1 1994

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Lipid bilayers
quantitative analysis
lipid
membrane
Electric potential
Membranes
Chemical analysis
Clamping devices
Membrane Lipids
Breakdown
Membrane
Quantitative analysis
prediction
rate

All Science Journal Classification (ASJC) codes

  • Energy(all)
  • Atmospheric Science
  • Earth and Planetary Sciences(all)
  • Management of Technology and Innovation

Cite this

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