Review: Extracellular matrix regulates tooth morphogenesis

Satoshi Fukumoto, Yoshihiko Yamada

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

Mineralized tissues are unique in that they use proteins to attract and organize calcium and phosphate ions into a structured mineral phase, thus precise knowledge of the expression and extracellular distribution of matrix proteins is very important to understand their function. Tooth development is regulated by sequential and reciprocal interactions between neural crest-derived mesenchymal cells and the oral environment. However, the precise molecular mechanisms that mediate interactions between epithelium and mesenchymal cells are not clear, although basement membrane (BM) components have been shown to play important roles in these regulatory events. In addition, the extracellular matrix layer, whose main components are laminin, collagen IV, nidogen, and sulfated proteoglycan, and the BM layer are both considered to be involved with cell proliferation and differentiation. During tooth morphogenesis, extracellular matrices are dramatically changed. Further, the BM components, laminin and collagen IV support dental epithelium; however, in the late stage, they begin the processes of enamel matrix secretion and calcification, after which the BM structure between the dental epithelium and mesenchyme disappears. In addition, tooth abnormalities associated with several kinds of human diseases that cause mutations in the extracellular matrix, as well as the molecular mechanisms of the basement membrane and enamel matrix during tooth morphogenesis, are not clearly understood. In our review, we discuss the role of the extracellular matrix, with focus on the BM and enamel matrix during tooth morphogenesis.

Original languageEnglish
Pages (from-to)220-226
Number of pages7
JournalConnective Tissue Research
Volume46
Issue number4-5
DOIs
Publication statusPublished - Jul 1 2005

Fingerprint

Morphogenesis
Basement Membrane
Extracellular Matrix
Tooth
Dental Enamel
Enamels
Epithelium
Laminin
Tooth Abnormalities
Collagen
Neural Crest
Extracellular Matrix Proteins
Mesoderm
Proteoglycans
Membrane structures
Minerals
Cell Differentiation
Cell proliferation
Cell Proliferation
Ions

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Nephrology
  • Cell Biology
  • Orthopedics and Sports Medicine

Cite this

Review : Extracellular matrix regulates tooth morphogenesis. / Fukumoto, Satoshi; Yamada, Yoshihiko.

In: Connective Tissue Research, Vol. 46, No. 4-5, 01.07.2005, p. 220-226.

Research output: Contribution to journalReview article

Fukumoto, Satoshi ; Yamada, Yoshihiko. / Review : Extracellular matrix regulates tooth morphogenesis. In: Connective Tissue Research. 2005 ; Vol. 46, No. 4-5. pp. 220-226.
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