Reviewing the current classification of inhibitor of growth family proteins

Motoko Unoki, Kensuke Kumamoto, Seiichi Takenoshita, Curtis C. Harris

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Inhibitor of growth (ING) family proteins have been defined as candidate tumor suppressors for more than a decade. Recent emerging results using siRNA and knockout mice are expanding the previous understanding of this protein family. The results of ING1 knockout mouse experiments revealed that ING1 has a protective effect on apoptosis. Our recent results showed that ING2 is overexpressed in colorectal cancer, and induces colon cancer cell invasion through an MMP13-dependent pathway. Knockdown of ING2 by siRNA induces premature senescence in normal human fibroblast cells, and apoptosis or cell cycle arrest in various adherent cancer cells. Taken together, these results suggest that ING2 may also have roles in cancer progression and/or malignant transformation under some conditions. Additionally, knockdown of ING4 and ING5 by siRNA shows an inhibitory effect on the transition from G2/M to G1 phase and DNA replication, respectively, suggesting that these proteins may play roles during cell proliferation in some context. ING family proteins may play dual roles, similar to transforming growth factor-β, which has tumor suppressor-like functions in normal epithelium and also oncogenic functions in invasive metastatic cancers. In the present article, we briefly review ING history and propose a possible interpretation of discrepancies between past and recent data.

Original languageEnglish
Pages (from-to)1173-1179
Number of pages7
JournalCancer Science
Volume100
Issue number7
DOIs
Publication statusPublished - Jun 23 2009
Externally publishedYes

Fingerprint

Growth Inhibitors
Small Interfering RNA
Neoplasms
Proteins
Knockout Mice
Colonic Neoplasms
Apoptosis
G1 Phase
Transforming Growth Factors
Cell Cycle Checkpoints
DNA Replication
Colorectal Neoplasms
Epithelium
Fibroblasts
History
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Reviewing the current classification of inhibitor of growth family proteins. / Unoki, Motoko; Kumamoto, Kensuke; Takenoshita, Seiichi; Harris, Curtis C.

In: Cancer Science, Vol. 100, No. 7, 23.06.2009, p. 1173-1179.

Research output: Contribution to journalReview article

Unoki, Motoko ; Kumamoto, Kensuke ; Takenoshita, Seiichi ; Harris, Curtis C. / Reviewing the current classification of inhibitor of growth family proteins. In: Cancer Science. 2009 ; Vol. 100, No. 7. pp. 1173-1179.
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