TY - JOUR
T1 - Rh-catalyzed direct enantioselective alkynylation of α-ketiminoesters
AU - Morisaki, Kazuhiro
AU - Sawa, Masanao
AU - Nomaguchi, Jun Ya
AU - Morimoto, Hiroyuki
AU - Takeuchi, Yosuke
AU - Mashima, Kazushi
AU - Ohshima, Takashi
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013/6/24
Y1 - 2013/6/24
N2 - A green way to amino acids: α-Tetrasubstituted α-amino acid derivatives are formed in high yield and enantioselectivity by using a Rh-catalyzed enantioselective alkynylation of α-ketiminoesters. This reaction, which involves a proton transfer and can be conducted at room temperature, has high substrate scope (see scheme; Cbz=benzyloxycarbonyl, Fmoc=9-fluorenylmethyloxycarbonyl).
AB - A green way to amino acids: α-Tetrasubstituted α-amino acid derivatives are formed in high yield and enantioselectivity by using a Rh-catalyzed enantioselective alkynylation of α-ketiminoesters. This reaction, which involves a proton transfer and can be conducted at room temperature, has high substrate scope (see scheme; Cbz=benzyloxycarbonyl, Fmoc=9-fluorenylmethyloxycarbonyl).
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U2 - 10.1002/chem.201301237
DO - 10.1002/chem.201301237
M3 - Article
C2 - 23670946
AN - SCOPUS:84879164787
SN - 0947-6539
VL - 19
SP - 8417
EP - 8420
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 26
ER -