RhCl3-catalyzed disulfide exchange reaction of insulin and dithiodiglycolic acid

Mieko Arisawa, Manabu Kuwajima, Atsushi Suwa, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

RhCl3 catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.

Original languageEnglish
Pages (from-to)1239-1248
Number of pages10
JournalHeterocycles
Volume80
Issue number2
DOIs
Publication statusPublished - Mar 1 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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