Rhenium-catalyzed regioselective synthesis of phenol derivatives from 1,3-diesters and terminal alkynes

Yoichiro Kuninobu, Takashi Iwanaga, Mitsumi Nishi, Kazuhiko Takai

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Treatment of malonates without a substituent at the active methylene moiety with terminal alkynes gave salicylates regioselectively. In contrast, when malonates bearing a substituent at the active methylene moiety were used, cyclic β-keto esters were generated regioselectively. Treatment of the formed cyclic β-keto esters with In(OTf)3 gave phenol derivatives via decarboxylation.

Original languageEnglish
Pages (from-to)894-895
Number of pages2
JournalChemistry Letters
Volume39
Issue number8
DOIs
Publication statusPublished - Jul 26 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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