Rhenium-catalyzed synthesis of naphthalene derivatives via insertion of aldehydes into a C-H bond

Yoichiro Kuninobu, Yuta Nishina, Kazuhiko Takai

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43 Citations (Scopus)


A rhenium complex, [ReBr(CO)3(THF)]2, catalyzed reactions of aromatic ketimines and aldehydes with dienophiles, followed by dehydration, to give naphthalene derivatives in good to excellent yields. This reaction proceeds via C-H bond activation, insertion of an aldehyde, intramolecular nucleophilic cyclization, reductive elimination, elimination of aniline and Diels-Alder reaction. After dehydration, naphthalene derivatives were formed.

Original languageEnglish
Pages (from-to)8463-8468
Number of pages6
Issue number35
Publication statusPublished - Aug 27 2007
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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