Rheological aspects of conformational change and molecular aggregation of macromolecules

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

When the temperature of a dilute polymer solution is changed gradually far below the Θ point, the conformation of individual polymer chains changes from a random coil to a compact globular state (coil-globule transition), followed by intermolecular aggregation owing to phase separation. In this chapter, the coil-globule transition and the aggregation behavior in dilute solutions of typical neutral synthetic homopolymers, poly(N-isopropylacrylamide) (PNIPAM) and poly(methyl methacrylate) (PMMA), are reviewed, and some rheological aspects of the kinetics of chain collapse and chain aggregation are demonstrated. The applicability of the rheological concepts derived from the aggregation behavior of synthetic homopolymers to that of intrinsically disordered proteins (IDPs) is considered.

Original languageEnglish
Title of host publicationNano/Micro Science and Technology in Biorheology
Subtitle of host publicationPrinciples, Methods, and Applications
PublisherSpringer Japan
Pages7-41
Number of pages35
ISBN (Electronic)9784431548867
ISBN (Print)9784431548850
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Macromolecules
Polymers
Agglomeration
Intrinsically Disordered Proteins
Polymethyl Methacrylate
Homopolymerization
Temperature
Polymer solutions
Polymethyl methacrylates
Phase separation
Conformations
Proteins
Kinetics
poly-N-isopropylacrylamide

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)

Cite this

Maki, Y. (2015). Rheological aspects of conformational change and molecular aggregation of macromolecules. In Nano/Micro Science and Technology in Biorheology: Principles, Methods, and Applications (pp. 7-41). Springer Japan. https://doi.org/10.1007/978-4-431-54886-7_2

Rheological aspects of conformational change and molecular aggregation of macromolecules. / Maki, Yasuyuki.

Nano/Micro Science and Technology in Biorheology: Principles, Methods, and Applications. Springer Japan, 2015. p. 7-41.

Research output: Chapter in Book/Report/Conference proceedingChapter

Maki, Y 2015, Rheological aspects of conformational change and molecular aggregation of macromolecules. in Nano/Micro Science and Technology in Biorheology: Principles, Methods, and Applications. Springer Japan, pp. 7-41. https://doi.org/10.1007/978-4-431-54886-7_2
Maki Y. Rheological aspects of conformational change and molecular aggregation of macromolecules. In Nano/Micro Science and Technology in Biorheology: Principles, Methods, and Applications. Springer Japan. 2015. p. 7-41 https://doi.org/10.1007/978-4-431-54886-7_2
Maki, Yasuyuki. / Rheological aspects of conformational change and molecular aggregation of macromolecules. Nano/Micro Science and Technology in Biorheology: Principles, Methods, and Applications. Springer Japan, 2015. pp. 7-41
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