Rheumatic fever-mimicking carditis as a first presentation of chronic active Epstein-Barr virus infection

Taikai Toubo, Shouichi Ohga, Hidetoshi Takada, Naohiro Suga, Akihiko Nomura, Takurou Ohno, Toshiro Hara

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A 7-y-old girl presented with prolonged fever, arrhythmia and cardiomegaly during the treatment course of group A β-haemolytic streptococcal pharyngitis. The isolated rheumatogenic strain M1 suggested the diagnosis of rheumatic fever. However, serous pericardial effusion contained high levels of Epstein-Barr virus (EBV) DNA. Clonally proliferating EBV+ T cells were determined in the circulation. The atypical carditis without valvitis was then complicated by coronary artery dilatations. Four months after the start of prednisolone plus antiviral/bacterial therapy, EBV+ T-cell lymphoma developed in the thigh. Conclusion: Atypical carditis may be a notable and life-threatening presentation of chronic active EBV infection to be differentiated from rheumatic fever.

Original languageEnglish
Pages (from-to)614-618
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Volume95
Issue number5
DOIs
Publication statusPublished - May 2006

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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