Rheumatic fever-mimicking carditis as a first presentation of chronic active Epstein-Barr virus infection

Taikai Toubo; Shouichi Ohga; Hidetoshi Takada; Naohiro Suga; Akihiko Nomura; Takurou Ohno; Toshiro Hara

doi:10.1080/08035250500371821

Rheumatic fever-mimicking carditis as a first presentation of chronic active Epstein-Barr virus infection

Taikai Toubo, Shouichi Ohga, Hidetoshi Takada, Naohiro Suga, Akihiko Nomura, Takurou Ohno, Toshiro Hara

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A 7-y-old girl presented with prolonged fever, arrhythmia and cardiomegaly during the treatment course of group A β-haemolytic streptococcal pharyngitis. The isolated rheumatogenic strain M1 suggested the diagnosis of rheumatic fever. However, serous pericardial effusion contained high levels of Epstein-Barr virus (EBV) DNA. Clonally proliferating EBV⁺ T cells were determined in the circulation. The atypical carditis without valvitis was then complicated by coronary artery dilatations. Four months after the start of prednisolone plus antiviral/bacterial therapy, EBV⁺ T-cell lymphoma developed in the thigh. Conclusion: Atypical carditis may be a notable and life-threatening presentation of chronic active EBV infection to be differentiated from rheumatic fever.

Original language	English
Pages (from-to)	614-618
Number of pages	5
Journal	Acta Paediatrica, International Journal of Paediatrics
Volume	95
Issue number	5
DOIs	https://doi.org/10.1080/08035250500371821
Publication status	Published - May 2006

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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10.1080/08035250500371821

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title = "Rheumatic fever-mimicking carditis as a first presentation of chronic active Epstein-Barr virus infection",

abstract = "A 7-y-old girl presented with prolonged fever, arrhythmia and cardiomegaly during the treatment course of group A β-haemolytic streptococcal pharyngitis. The isolated rheumatogenic strain M1 suggested the diagnosis of rheumatic fever. However, serous pericardial effusion contained high levels of Epstein-Barr virus (EBV) DNA. Clonally proliferating EBV+ T cells were determined in the circulation. The atypical carditis without valvitis was then complicated by coronary artery dilatations. Four months after the start of prednisolone plus antiviral/bacterial therapy, EBV+ T-cell lymphoma developed in the thigh. Conclusion: Atypical carditis may be a notable and life-threatening presentation of chronic active EBV infection to be differentiated from rheumatic fever.",

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AU - Toubo, Taikai

AU - Ohga, Shouichi

AU - Takada, Hidetoshi

AU - Suga, Naohiro

AU - Nomura, Akihiko

AU - Ohno, Takurou

AU - Hara, Toshiro

PY - 2006/5

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AB - A 7-y-old girl presented with prolonged fever, arrhythmia and cardiomegaly during the treatment course of group A β-haemolytic streptococcal pharyngitis. The isolated rheumatogenic strain M1 suggested the diagnosis of rheumatic fever. However, serous pericardial effusion contained high levels of Epstein-Barr virus (EBV) DNA. Clonally proliferating EBV+ T cells were determined in the circulation. The atypical carditis without valvitis was then complicated by coronary artery dilatations. Four months after the start of prednisolone plus antiviral/bacterial therapy, EBV+ T-cell lymphoma developed in the thigh. Conclusion: Atypical carditis may be a notable and life-threatening presentation of chronic active EBV infection to be differentiated from rheumatic fever.

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Rheumatic fever-mimicking carditis as a first presentation of chronic active Epstein-Barr virus infection

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