Rhodium-catalyzed alkylthio exchange reaction of thioester and disulfide

Mieko Arisawa, Tomohiro Kubota, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

The Wilkinson complex RhCl(PPh3)3 catalyzes equilibrating alkylthio exchange reaction of thioesters with disulfides. The treatment of a thioester and a dialkyl disulfide in refluxing diethyl ketone in the presence of RhCl(PPh3)3 (2.5 mol %) for 1.5 h gave an alkylthio exchanged thioester. The reaction of S-methyl ester was conducted shifting the equilibrium by removing volatile dimethyl disulfide.

Original languageEnglish
Pages (from-to)1975-1978
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number12
DOIs
Publication statusPublished - Mar 17 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Rhodium-catalyzed alkylthio exchange reaction of thioester and disulfide'. Together they form a unique fingerprint.

Cite this