Rhodium-catalyzed oxidation of unprotected peptide thiols to disulfides with oxygen in water

Mieko Arisawa, Kohei Fukumoto, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Unprotected peptide thiols are efficiently oxidized to peptide disulfides in homogeneous water. The oxidation reaction proceeds under ambient pressure of oxygen (1 atm), using a readily available RhCl3 catalyst. The reaction can also tolerate amino acid residues Gly, Ala, Val, Len, Ile, Phe, Ser, Tyr, Lys, Asp, Gln, His, Trp, and Met. The mechanism involving the formation of unstable sulfenic acid is provided.

Original languageEnglish
Pages (from-to)15060-15064
Number of pages5
JournalACS Catalysis
Volume10
Issue number24
DOIs
Publication statusPublished - Dec 18 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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