Rhodium-catalyzed synthesis of 2,3-diaryl-1,4-diketones via oxidative coupling of benzyl ketones using α-thioketone oxidizing reagent

Mieko Arisawa, Guangzhe Li, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

RhH(PPh3)4 and 1,2-bis(diphenylphosphino)benzene (dppBz) catalyzed the oxidative coupling reaction of aryl benzyl ketones giving 2,3-diaryl-1,4-diketones in high yields. 3,3-Dimethyl-1-methylthio-2-butanone was used as the oxidizing reagent, which was converted to 3,3-dimethyl-2- butanone and dimethyl disulfide. Rhodium enolates were catalytically formed from ketones, which underwent oxidative coupling using an organosulfur reagent.

Original languageEnglish
Pages (from-to)1298-1301
Number of pages4
JournalTetrahedron Letters
Volume54
Issue number10
DOIs
Publication statusPublished - Mar 6 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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