Rhodium-catalyzed synthesis of benzofurans by the reaction of ketones and O-difluorobenzenes

Mieko Arisawa, Soichiro Nakane, Manabu Kuwajima, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

In the presence of catalytic amounts of RhH(PPh3)4 and 1,2- bis(diphenylphosphino)ethane (dppe), ketones reacted with o-difluorobenzenes giving benzofurans in high yields. The ?-arylation of ketones and furan cyclization proceeded without using a base. Benzofuran cyclization was applied to substituted pentafluorobenzenes to give 6-substituted-4,5,7- trifluorobenzofuranes.

Original languageEnglish
Pages (from-to)1103-1118
Number of pages16
JournalHeterocycles
Volume86
Issue number2
DOIs
Publication statusPublished - 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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