Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl)ureas Involving an Equilibrium Shift

Mieko Arisawa, Taro Mizuno, Kanako Nozawa-Kumada, Kaori Itto-Nakama, Miyu Furuta, Saori Tanii

Research output: Contribution to journalArticlepeer-review

Abstract

Unsymmetric di(heteroaryl)ureas such as HetAr1-NHCONH-HetAr2 are efficiently synthesized from two symmetric ureas, HetAr1-NHCONH-HetAr1 and HetAr2-NHCONH-HetAr2, by rhodium-catalyzed exchange reactions. The equilibrium in some of the reactions can be shifted to the formation of unsymmetric ureas by the aggregation of the dimers formed by inter- A nd intramolecular hydrogen bonding.

Original languageEnglish
JournalOrganic letters
DOIs
Publication statusAccepted/In press - 2021

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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