Rhodium(I)/Chiral Diene-Catalyzed Enantioselective Addition of Boronic Acids to N-Unsubstituted Isatin-Derived Ketimines

Ryohei Yonesaki, Ibuki Kusagawa, Hiroyuki Morimoto, Tamio Hayashi, Takashi Ohshima

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Enantioselective addition of boronic acids to N-unsubstituted isatin-derived ketimines was realized using rhodium(I)/chiral diene catalysts. The reactions can be performed in the presence of catalytic amounts of a base to give adducts in high yield with high enantioselectivity. Preliminary mechanistic information including a computational model to explain the observed enantioselectivity is also provided.

Original languageEnglish
Pages (from-to)499-502
Number of pages4
JournalChemistry - An Asian Journal
Volume15
Issue number4
DOIs
Publication statusAccepted/In press - Jan 1 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

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