Rice α-globulin decreases serum cholesterol concentrations in rats fed a hypercholesterolemic diet and ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice

Li Tao Tong, Yumiko Fujimoto, Naoki Shimizu, Mariko Tsukino, Taiki Akasaka, Yukiko Kato, Wakako Iwamoto, Sawako Shiratake, Katsumi Imaizumi, Masao Sato

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Abstract

The hypocholesterolemic and antiatherogenic effects of rice α-globulin remain unclear. We investigated the hypocholesterolemic effect of rice α-globulin in rats fed a hypercholesterolemic diet. The rats were divided into 4 groups and were orally administrated the following three proteins or a vehicle for 4 weeks: rice protein, rice α-globulin, or soy β-conglycinin at a dose of 100 mg/kg body weight or carboxymethylcellulose to the control rats. In the rice α-globulin group, serum cholesterol concentrations were 28% lower than the control group and fecal neutral steroid excretion was increased by 30%. The hypocholesterolemic effect of rice α-globulin was equal to soy β-conglycinin in SD rats fed the hypercholesterolemic diet. However, the serum cholesterol concentrations in the rice protein group did not change compared to the control group. To investigate the antiatherogenic effects of rice α-globulin, male apolipoprotein E-deficient mice were orally administered the same dose of rice α-globulin for 9 weeks. The en face lesion area in the aorta was 46% lower than in the control group. In conclusion, administration of rice α-globulin improves hypercholesterolemia in rats fed a hypercholesterolemic diet by increasing the fecal excretion of neutral sterols, and inhibits atherosclerosis development in apolipoprotein E-deficient mice. The anti-atherosclerotic effect exerts by mechanism(s) other than the regulation of serum MCP-1 and NO concentrations.

Original languageEnglish
Pages (from-to)194-200
Number of pages7
JournalFood Chemistry
Volume132
Issue number1
DOIs
Publication statusPublished - May 1 2012

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Serum Globulins
apolipoprotein E
Globulins
Apolipoproteins E
Nutrition
globulins
Rats
Cholesterol
cholesterol
Diet
rice
rats
mice
diet
rice protein
cholesteremic effect
excretion
Control Groups
Rat control
Carboxymethylcellulose Sodium

All Science Journal Classification (ASJC) codes

  • Food Science
  • Analytical Chemistry
  • Medicine(all)

Cite this

Rice α-globulin decreases serum cholesterol concentrations in rats fed a hypercholesterolemic diet and ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice. / Tong, Li Tao; Fujimoto, Yumiko; Shimizu, Naoki; Tsukino, Mariko; Akasaka, Taiki; Kato, Yukiko; Iwamoto, Wakako; Shiratake, Sawako; Imaizumi, Katsumi; Sato, Masao.

In: Food Chemistry, Vol. 132, No. 1, 01.05.2012, p. 194-200.

Research output: Contribution to journalArticle

Tong, Li Tao ; Fujimoto, Yumiko ; Shimizu, Naoki ; Tsukino, Mariko ; Akasaka, Taiki ; Kato, Yukiko ; Iwamoto, Wakako ; Shiratake, Sawako ; Imaizumi, Katsumi ; Sato, Masao. / Rice α-globulin decreases serum cholesterol concentrations in rats fed a hypercholesterolemic diet and ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice. In: Food Chemistry. 2012 ; Vol. 132, No. 1. pp. 194-200.
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