Right isomerism of the brain in inversus viscerum mutant mice

Ryosuke Kawakami, Alice Dobi, Ryuichi Shigemoto, Isao Ito

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Left-right (L-R) asymmetry is a fundamental feature of higher-order neural function. However, the molecular basis of brain asymmetry remains unclear. We recently reported L-R asymmetry of hippocampal circuitry caused by differential allocation of N-methyl-O-aspartate receptor (NMDAR) subunit GluRε2 (NR2B) in hippocambal synapses. Using electrophysiology and immunocytochemistry, here we analyzed the hippocampal circuitry of the inversus viscerum (iv) mouse that has a randomized laterality of internal organs. The iv mouse hippocampus lacks L-R asymmetry, it exhibits right isomerism in the synaptic distribution of the ε2 subunit, irrespective of the laterality of visceral organs. This independent right isomerism of the hippocampus is the first evidence that a distinct mechanism downstream of the iv mutation generates brain asymmetry.

Original languageEnglish
Article numbere1945
JournalPloS one
Volume3
Issue number4
DOIs
Publication statusPublished - Apr 16 2008

Fingerprint

Isomerism
isomerization
hippocampus
Hippocampus
Brain
Electrophysiology
brain
electrophysiology
mutants
mice
immunocytochemistry
aspartic acid
synapse
Synapses
Immunohistochemistry
mutation
Mutation
receptors
aspartic acid receptor

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kawakami, R., Dobi, A., Shigemoto, R., & Ito, I. (2008). Right isomerism of the brain in inversus viscerum mutant mice. PloS one, 3(4), [e1945]. https://doi.org/10.1371/journal.pone.0001945

Right isomerism of the brain in inversus viscerum mutant mice. / Kawakami, Ryosuke; Dobi, Alice; Shigemoto, Ryuichi; Ito, Isao.

In: PloS one, Vol. 3, No. 4, e1945, 16.04.2008.

Research output: Contribution to journalArticle

Kawakami, R, Dobi, A, Shigemoto, R & Ito, I 2008, 'Right isomerism of the brain in inversus viscerum mutant mice', PloS one, vol. 3, no. 4, e1945. https://doi.org/10.1371/journal.pone.0001945
Kawakami, Ryosuke ; Dobi, Alice ; Shigemoto, Ryuichi ; Ito, Isao. / Right isomerism of the brain in inversus viscerum mutant mice. In: PloS one. 2008 ; Vol. 3, No. 4.
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