Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats

Shota Yamamoto, Nobuaki Egashira, Makoto Tsuda, Satohiro Masuda

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Abstract

Oxaliplatin causes acute cold hypersensitivity in most patients. We previously reported oxalate derived from oxaliplatin induced cold allodynia via overexpression of transient receptor potential melastatin 8 (TRPM8) in the dorsal root ganglion (DRG) in rats. In this study, we examined the effect of riluzole on oxaliplatin-induced cold allodynia. In cultured DRG neurons, riluzole suppressed oxalate-induced increase of the number of menthol (TRPM8 agonist)-sensitive cells. Moreover, riluzole prevented cold allodynia and increase in levels of TRPM8 mRNA in oxaliplatin-treated rats. These results suggest that riluzole prevents oxaliplatin-induced cold allodynia via inhibition of TRPM8 overexpression in the DRG.

Original languageEnglish
Pages (from-to)214-217
Number of pages4
JournalJournal of Pharmacological Sciences
Volume138
Issue number3
DOIs
Publication statusPublished - Nov 2018

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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