Rings-on-a-string chain structure in DNA

Naomi Miyazawa, Takahiro Sakaue, Kenichi Yoshikawa, Raoul Zana

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Using fluorescence microscopy (FM), which permits the observation of single molecules, we found that a pearling structure is generated on a single long DNA molecule upon the addition of a gemini (dimeric) surfactant. This pearling structure was further investigated by performing atomic force microscopy measurements on the same DNA molecules as observed by FM. These observations revealed that the pearling structure is composed of many rings that are interconnected by elongated coil parts along a single DNA molecule, i.e., rings-on-a-string structure. The mechanism of the formation of such an intrachain segregated structure in terms of microphase separation on a single polyelectrolyte chain is discussed.

Original languageEnglish
Article number044902
JournalJournal of Chemical Physics
Volume122
Issue number4
DOIs
Publication statusPublished - Jan 1 2005

Fingerprint

strings
deoxyribonucleic acid
Molecules
Fluorescence microscopy
rings
DNA
molecules
microscopy
Microphase separation
fluorescence
Polyelectrolytes
Surface-Active Agents
Atomic force microscopy
coils
surfactants
atomic force microscopy

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Cite this

Miyazawa, N., Sakaue, T., Yoshikawa, K., & Zana, R. (2005). Rings-on-a-string chain structure in DNA. Journal of Chemical Physics, 122(4), [044902]. https://doi.org/10.1063/1.1839860

Rings-on-a-string chain structure in DNA. / Miyazawa, Naomi; Sakaue, Takahiro; Yoshikawa, Kenichi; Zana, Raoul.

In: Journal of Chemical Physics, Vol. 122, No. 4, 044902, 01.01.2005.

Research output: Contribution to journalArticle

Miyazawa, N, Sakaue, T, Yoshikawa, K & Zana, R 2005, 'Rings-on-a-string chain structure in DNA', Journal of Chemical Physics, vol. 122, no. 4, 044902. https://doi.org/10.1063/1.1839860
Miyazawa N, Sakaue T, Yoshikawa K, Zana R. Rings-on-a-string chain structure in DNA. Journal of Chemical Physics. 2005 Jan 1;122(4). 044902. https://doi.org/10.1063/1.1839860
Miyazawa, Naomi ; Sakaue, Takahiro ; Yoshikawa, Kenichi ; Zana, Raoul. / Rings-on-a-string chain structure in DNA. In: Journal of Chemical Physics. 2005 ; Vol. 122, No. 4.
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