TY - JOUR
T1 - RIP kinase-mediated necrosis as an alternative mechanism of photoreceptor death
AU - Murakami, Yusuke
AU - Miller, Joan W.
AU - Vavvas, Demetrios G.
PY - 2011/6
Y1 - 2011/6
N2 - Photoreceptor cell death is the terminal event in a variety of retinal disorders including age-related macular degeneration, retinitis pigmentosa, and retinal detachment. Apoptosis has been thought to be the major form of cell death in these diseases, however accumulating evidence suggests that another pathway, programmed necrosis is also important. Recent studies have shown that, when caspase pathways are blocked, receptor interacting protein (RIP) kinases promote necrosis and overcome apoptosis inhibition. Therefore, targeting of both caspase and RIP kinase pathways are required for effective photoreceptor protection. Here, we summarize the current knowledge of RIP kinase-mediated necrotic signaling and its contribution to photoreceptor death.
AB - Photoreceptor cell death is the terminal event in a variety of retinal disorders including age-related macular degeneration, retinitis pigmentosa, and retinal detachment. Apoptosis has been thought to be the major form of cell death in these diseases, however accumulating evidence suggests that another pathway, programmed necrosis is also important. Recent studies have shown that, when caspase pathways are blocked, receptor interacting protein (RIP) kinases promote necrosis and overcome apoptosis inhibition. Therefore, targeting of both caspase and RIP kinase pathways are required for effective photoreceptor protection. Here, we summarize the current knowledge of RIP kinase-mediated necrotic signaling and its contribution to photoreceptor death.
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U2 - 10.18632/oncotarget.286
DO - 10.18632/oncotarget.286
M3 - Article
C2 - 21670490
AN - SCOPUS:80555133359
VL - 2
SP - 497
EP - 509
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 6
ER -