RIP kinase-mediated necrosis as an alternative mechanism of photoreceptor death

Yusuke Murakami, Joan W. Miller, Demetrios G. Vavvas

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Photoreceptor cell death is the terminal event in a variety of retinal disorders including age-related macular degeneration, retinitis pigmentosa, and retinal detachment. Apoptosis has been thought to be the major form of cell death in these diseases, however accumulating evidence suggests that another pathway, programmed necrosis is also important. Recent studies have shown that, when caspase pathways are blocked, receptor interacting protein (RIP) kinases promote necrosis and overcome apoptosis inhibition. Therefore, targeting of both caspase and RIP kinase pathways are required for effective photoreceptor protection. Here, we summarize the current knowledge of RIP kinase-mediated necrotic signaling and its contribution to photoreceptor death.

Original languageEnglish
Pages (from-to)497-509
Number of pages13
JournalOncotarget
Volume2
Issue number6
DOIs
Publication statusPublished - Jun 2011

All Science Journal Classification (ASJC) codes

  • Oncology

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