Risk factors for chronic graft-versus-host disease after allogeneic stem cell transplantation in children

M. Kondo, S. Kojima, K. Horibe, Koji Kato, T. Matsuyama

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Abstract

We analyzed the incidence and risk factors for chronic graft-versus-host disease (GVHD) in 265 children undergoing allogeneic stem cell transplantation (SCT) who survived longer than 3 months post SCT. Patients transplanted from HLA-mismatched related donors and matched unrelated donors were included. Fifty-five patients developed chronic GVHD between 1 and 25 months after SCT, and the 5-year cumurative incidence of chronic GVHD was 22%. By multivariate analysis, acute GVHD (P = 0.004), malignant disease (P = 0.004), recipient age (≥10 years) (P = 0.01) and a female donor to male recipient (P = 0.035) were significant risk factors for chronic GVHD. When acute GVHD was excluded from the multivariate analysis, malignant disease (P = 0.002) and older recipient age (P = 0.007) were identified. The incidence of chronic GVHD in this childhood study was lower than that observed in adults, and recipient age was an important factor in childhood SCT. The high incidence associated with malignant disease may be affected by changes in GVHD prophylaxis in order to ensure graft-versus-tumor effects.

Original languageEnglish
Pages (from-to)727-730
Number of pages4
JournalBone Marrow Transplantation
Volume27
Issue number7
DOIs
Publication statusPublished - May 17 2001

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Stem Cell Transplantation
Graft vs Host Disease
Incidence
Multivariate Analysis
Tissue Donors
Unrelated Donors
Transplants

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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Risk factors for chronic graft-versus-host disease after allogeneic stem cell transplantation in children. / Kondo, M.; Kojima, S.; Horibe, K.; Kato, Koji; Matsuyama, T.

In: Bone Marrow Transplantation, Vol. 27, No. 7, 17.05.2001, p. 727-730.

Research output: Contribution to journalArticle

Kondo, M. ; Kojima, S. ; Horibe, K. ; Kato, Koji ; Matsuyama, T. / Risk factors for chronic graft-versus-host disease after allogeneic stem cell transplantation in children. In: Bone Marrow Transplantation. 2001 ; Vol. 27, No. 7. pp. 727-730.
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