Risk factors for development of systemic lupus erythematosus among Japanese females: medical history and reproductive factors

the Kyushu Sapporo SLE (KYSS) Study Group

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: The aim of the present study was to examine the influence of medical history and reproductive factors on the development of systemic lupus erythematosus (SLE) among Japanese females. Methods: One hundred and sixty female SLE patients and 660 female volunteers were studied in a case–control study. Unconditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CIs). Results: The present study demonstrated that medical histories of operations without blood transfusion (OR = 1.64, 95% CI = 1.10–2.44) and operations with blood transfusion (OR = 4.44, 95% CI = 1.93–10.23) increased the risk of SLE with adjustment for age, region, smoking and alcohol drinking. Among 91 SLE patients and 284 control subjects who had the experience of married life, nulliparity (OR = 2.29, 95% CI = 1.05–5.17), increased the risk of SLE, while the risk decreased according to the number of children (one to two vs. none, OR = 0.27, 95% CI = 0.10–0.73; three or more vs. none, OR = 0.14, 95% CI = 0.04–0.51; P for trend < 0.01). Conclusions: Several factors are suggested to be associated with the development of SLE among Japanese females.

Original languageEnglish
Pages (from-to)76-83
Number of pages8
JournalInternational Journal of Rheumatic Diseases
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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Reproductive History
Systemic Lupus Erythematosus
Odds Ratio
Confidence Intervals
Blood Transfusion
Life Change Events
Parity
Alcohol Drinking
Volunteers
Logistic Models
Smoking

All Science Journal Classification (ASJC) codes

  • Rheumatology

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Risk factors for development of systemic lupus erythematosus among Japanese females : medical history and reproductive factors. / the Kyushu Sapporo SLE (KYSS) Study Group.

In: International Journal of Rheumatic Diseases, Vol. 20, No. 1, 01.01.2017, p. 76-83.

Research output: Contribution to journalArticle

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abstract = "Aim: The aim of the present study was to examine the influence of medical history and reproductive factors on the development of systemic lupus erythematosus (SLE) among Japanese females. Methods: One hundred and sixty female SLE patients and 660 female volunteers were studied in a case–control study. Unconditional logistic regression was used to compute odds ratios (OR) and 95{\%} confidence intervals (CIs). Results: The present study demonstrated that medical histories of operations without blood transfusion (OR = 1.64, 95{\%} CI = 1.10–2.44) and operations with blood transfusion (OR = 4.44, 95{\%} CI = 1.93–10.23) increased the risk of SLE with adjustment for age, region, smoking and alcohol drinking. Among 91 SLE patients and 284 control subjects who had the experience of married life, nulliparity (OR = 2.29, 95{\%} CI = 1.05–5.17), increased the risk of SLE, while the risk decreased according to the number of children (one to two vs. none, OR = 0.27, 95{\%} CI = 0.10–0.73; three or more vs. none, OR = 0.14, 95{\%} CI = 0.04–0.51; P for trend < 0.01). Conclusions: Several factors are suggested to be associated with the development of SLE among Japanese females.",
author = "{the Kyushu Sapporo SLE (KYSS) Study Group} and Masakazu Washio and Hiroki Takahashi and Gen Kobashi and Chikako Kiyohara and Chikako Kiyohara and Toyoko Asami and Yuichiro Ide and Tatsuya Atsumi and Takahiko Horiuchi and Takahiko Horiuchi and Hiroko Kodama and Koichi Akashi and Mine Harada and Koichi Akashi and Takao Hotokebuchi and Kohei Nagasawa and Osamu Ushiyama and Mitsuru Mori and Asae Oura and Yasuhisa Sinomura and Hiromu Suzuki and Motohisa Yamamoto and Takashi Abe and Hisato Tanaka and Tetsuya Horita and Shinsuke Yasuda and Norihiko Nogami and Kazushi Okamoto and Naomasa Sakamoto and Satoshi Sasaki and Yoshihiro Miyake and Tetsuji Yokoyama and Masayo Oumi and Yoshio Hirota and Yutaka Inaba and Masaki Nagai",
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AU - the Kyushu Sapporo SLE (KYSS) Study Group

AU - Washio, Masakazu

AU - Takahashi, Hiroki

AU - Kobashi, Gen

AU - Kiyohara, Chikako

AU - Kiyohara, Chikako

AU - Asami, Toyoko

AU - Ide, Yuichiro

AU - Atsumi, Tatsuya

AU - Horiuchi, Takahiko

AU - Horiuchi, Takahiko

AU - Kodama, Hiroko

AU - Akashi, Koichi

AU - Harada, Mine

AU - Akashi, Koichi

AU - Hotokebuchi, Takao

AU - Nagasawa, Kohei

AU - Ushiyama, Osamu

AU - Mori, Mitsuru

AU - Oura, Asae

AU - Sinomura, Yasuhisa

AU - Suzuki, Hiromu

AU - Yamamoto, Motohisa

AU - Abe, Takashi

AU - Tanaka, Hisato

AU - Horita, Tetsuya

AU - Yasuda, Shinsuke

AU - Nogami, Norihiko

AU - Okamoto, Kazushi

AU - Sakamoto, Naomasa

AU - Sasaki, Satoshi

AU - Miyake, Yoshihiro

AU - Yokoyama, Tetsuji

AU - Oumi, Masayo

AU - Hirota, Yoshio

AU - Inaba, Yutaka

AU - Nagai, Masaki

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Aim: The aim of the present study was to examine the influence of medical history and reproductive factors on the development of systemic lupus erythematosus (SLE) among Japanese females. Methods: One hundred and sixty female SLE patients and 660 female volunteers were studied in a case–control study. Unconditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CIs). Results: The present study demonstrated that medical histories of operations without blood transfusion (OR = 1.64, 95% CI = 1.10–2.44) and operations with blood transfusion (OR = 4.44, 95% CI = 1.93–10.23) increased the risk of SLE with adjustment for age, region, smoking and alcohol drinking. Among 91 SLE patients and 284 control subjects who had the experience of married life, nulliparity (OR = 2.29, 95% CI = 1.05–5.17), increased the risk of SLE, while the risk decreased according to the number of children (one to two vs. none, OR = 0.27, 95% CI = 0.10–0.73; three or more vs. none, OR = 0.14, 95% CI = 0.04–0.51; P for trend < 0.01). Conclusions: Several factors are suggested to be associated with the development of SLE among Japanese females.

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