Risk factors for incisional hernia after hepatic resection for hepatocellular carcinoma in patients with liver cirrhosis

Hiroto Kayashima, Takashi Maeda, Noboru Harada, Takanobu Masuda, Atsushi Guntani, Shuhei Ito, Ayumi Matsuyama, Motohiro Hamatake, Shinichi Tsutsui, Hiroyuki Matsuda, Teruyoshi Ishida

Research output: Contribution to journalArticle

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Abstract

Background The risk factors for incisional hernia (IH) and the association between liver fibrosis and IH after hepatic resection in patients with hepatocellular carcinoma (HCC) with liver cirrhosis (LC) are still unclear. We aimed to evaluate the rate of IH and to assess the effect of perioperative factors, including serum markers for liver fibrosis, on the risk of IH. Methods A total of 192 patients with HCC with LC who received hepatectomy were retrospectively analyzed. The primary end point was the incidence rate of IH and the secondary end points were associations between IH and 22 clinical factors. Results IH was diagnosed in 60 (31.3%) patients. The estimated incidence rates were 19.8% at 12 months, 32.5% at 36 months, and 38.8% at 60 months. In multivariable analysis, the presence of postoperative intractable ascites (odds ratio 24.83, P =.0003), abdominal wall closure by a single-layer mass closure with a continuous running suture (odds ratio 4.59, P =.0143), preoperative body mass index ≥25 kg/m2 (odds ratio 3.36, P =.0025), and preoperative serum N-terminal pro-peptide of type IV collagen 7S domain (P4NP 7S) levels ≥5 ng/mL (odds ratio 3.13, P =.0234) were independent risk factors. Conclusion There are several risk factors for IH after hepatic resection in HCC patients with LC. Preoperative serum P4NP 7S levels ≥5 ng/mL are a useful predictive marker, and abdominal wall closure with a continuous running suture by a single-layer mass closure should be avoided.

Original languageEnglish
Pages (from-to)1669-1675
Number of pages7
JournalSurgery (United States)
Volume158
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

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Liver Cirrhosis
Hepatocellular Carcinoma
Liver
Odds Ratio
Abdominal Wall
Sutures
Collagen Type IV
Incisional Hernia
Incidence
Hepatectomy
Serum
Ascites
Body Mass Index
Biomarkers
Peptides

All Science Journal Classification (ASJC) codes

  • Surgery

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Risk factors for incisional hernia after hepatic resection for hepatocellular carcinoma in patients with liver cirrhosis. / Kayashima, Hiroto; Maeda, Takashi; Harada, Noboru; Masuda, Takanobu; Guntani, Atsushi; Ito, Shuhei; Matsuyama, Ayumi; Hamatake, Motohiro; Tsutsui, Shinichi; Matsuda, Hiroyuki; Ishida, Teruyoshi.

In: Surgery (United States), Vol. 158, No. 6, 01.12.2015, p. 1669-1675.

Research output: Contribution to journalArticle

Kayashima, H, Maeda, T, Harada, N, Masuda, T, Guntani, A, Ito, S, Matsuyama, A, Hamatake, M, Tsutsui, S, Matsuda, H & Ishida, T 2015, 'Risk factors for incisional hernia after hepatic resection for hepatocellular carcinoma in patients with liver cirrhosis', Surgery (United States), vol. 158, no. 6, pp. 1669-1675. https://doi.org/10.1016/j.surg.2015.06.001
Kayashima, Hiroto ; Maeda, Takashi ; Harada, Noboru ; Masuda, Takanobu ; Guntani, Atsushi ; Ito, Shuhei ; Matsuyama, Ayumi ; Hamatake, Motohiro ; Tsutsui, Shinichi ; Matsuda, Hiroyuki ; Ishida, Teruyoshi. / Risk factors for incisional hernia after hepatic resection for hepatocellular carcinoma in patients with liver cirrhosis. In: Surgery (United States). 2015 ; Vol. 158, No. 6. pp. 1669-1675.
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abstract = "Background The risk factors for incisional hernia (IH) and the association between liver fibrosis and IH after hepatic resection in patients with hepatocellular carcinoma (HCC) with liver cirrhosis (LC) are still unclear. We aimed to evaluate the rate of IH and to assess the effect of perioperative factors, including serum markers for liver fibrosis, on the risk of IH. Methods A total of 192 patients with HCC with LC who received hepatectomy were retrospectively analyzed. The primary end point was the incidence rate of IH and the secondary end points were associations between IH and 22 clinical factors. Results IH was diagnosed in 60 (31.3{\%}) patients. The estimated incidence rates were 19.8{\%} at 12 months, 32.5{\%} at 36 months, and 38.8{\%} at 60 months. In multivariable analysis, the presence of postoperative intractable ascites (odds ratio 24.83, P =.0003), abdominal wall closure by a single-layer mass closure with a continuous running suture (odds ratio 4.59, P =.0143), preoperative body mass index ≥25 kg/m2 (odds ratio 3.36, P =.0025), and preoperative serum N-terminal pro-peptide of type IV collagen 7S domain (P4NP 7S) levels ≥5 ng/mL (odds ratio 3.13, P =.0234) were independent risk factors. Conclusion There are several risk factors for IH after hepatic resection in HCC patients with LC. Preoperative serum P4NP 7S levels ≥5 ng/mL are a useful predictive marker, and abdominal wall closure with a continuous running suture by a single-layer mass closure should be avoided.",
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T1 - Risk factors for incisional hernia after hepatic resection for hepatocellular carcinoma in patients with liver cirrhosis

AU - Kayashima, Hiroto

AU - Maeda, Takashi

AU - Harada, Noboru

AU - Masuda, Takanobu

AU - Guntani, Atsushi

AU - Ito, Shuhei

AU - Matsuyama, Ayumi

AU - Hamatake, Motohiro

AU - Tsutsui, Shinichi

AU - Matsuda, Hiroyuki

AU - Ishida, Teruyoshi

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background The risk factors for incisional hernia (IH) and the association between liver fibrosis and IH after hepatic resection in patients with hepatocellular carcinoma (HCC) with liver cirrhosis (LC) are still unclear. We aimed to evaluate the rate of IH and to assess the effect of perioperative factors, including serum markers for liver fibrosis, on the risk of IH. Methods A total of 192 patients with HCC with LC who received hepatectomy were retrospectively analyzed. The primary end point was the incidence rate of IH and the secondary end points were associations between IH and 22 clinical factors. Results IH was diagnosed in 60 (31.3%) patients. The estimated incidence rates were 19.8% at 12 months, 32.5% at 36 months, and 38.8% at 60 months. In multivariable analysis, the presence of postoperative intractable ascites (odds ratio 24.83, P =.0003), abdominal wall closure by a single-layer mass closure with a continuous running suture (odds ratio 4.59, P =.0143), preoperative body mass index ≥25 kg/m2 (odds ratio 3.36, P =.0025), and preoperative serum N-terminal pro-peptide of type IV collagen 7S domain (P4NP 7S) levels ≥5 ng/mL (odds ratio 3.13, P =.0234) were independent risk factors. Conclusion There are several risk factors for IH after hepatic resection in HCC patients with LC. Preoperative serum P4NP 7S levels ≥5 ng/mL are a useful predictive marker, and abdominal wall closure with a continuous running suture by a single-layer mass closure should be avoided.

AB - Background The risk factors for incisional hernia (IH) and the association between liver fibrosis and IH after hepatic resection in patients with hepatocellular carcinoma (HCC) with liver cirrhosis (LC) are still unclear. We aimed to evaluate the rate of IH and to assess the effect of perioperative factors, including serum markers for liver fibrosis, on the risk of IH. Methods A total of 192 patients with HCC with LC who received hepatectomy were retrospectively analyzed. The primary end point was the incidence rate of IH and the secondary end points were associations between IH and 22 clinical factors. Results IH was diagnosed in 60 (31.3%) patients. The estimated incidence rates were 19.8% at 12 months, 32.5% at 36 months, and 38.8% at 60 months. In multivariable analysis, the presence of postoperative intractable ascites (odds ratio 24.83, P =.0003), abdominal wall closure by a single-layer mass closure with a continuous running suture (odds ratio 4.59, P =.0143), preoperative body mass index ≥25 kg/m2 (odds ratio 3.36, P =.0025), and preoperative serum N-terminal pro-peptide of type IV collagen 7S domain (P4NP 7S) levels ≥5 ng/mL (odds ratio 3.13, P =.0234) were independent risk factors. Conclusion There are several risk factors for IH after hepatic resection in HCC patients with LC. Preoperative serum P4NP 7S levels ≥5 ng/mL are a useful predictive marker, and abdominal wall closure with a continuous running suture by a single-layer mass closure should be avoided.

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JO - Surgery

JF - Surgery

SN - 0039-6060

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