Risk factors for pericardial effusion in patients with stage i esophageal cancer treated with chemoradiotherapy

Keisuke Tamari, Fumiaki Isohashi, Yuichi Akino, Osamu Suzuki, Yuji Seo, Yasuo Yoshioka, Yoshito Hayashi, Tsutomu Nishida, Tetsuo Takehara, Masaki Mori, Yuichiro Doki, Kazuhiko Ogawa

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Aim: We investigated clinical and dosimetric factors influencing the risk of developing pericardial effusion (PCE) in patients with Stage I esophageal cancer undergoing definitive chemoradiotherapy. Patients and Methods: Sixtynine patients with Stage I esophageal cancer who underwent definitive chemoradiotherapy were retrospectively analyzed. Treatment comprised of three-dimensional conformal radiotherapy (60 Gy in 30 fractions) with concurrent chemotherapy. Clinical and dosimetric factors associated with PCE development were analyzed. Results: The median follow-up was 37 months (range=8-111 months); the crude PCE incidence rate was 52.2%. Grade 2 and 3 incidence rate was 47.8% and 4.3%, respectively. The median time to PCE onset was 5.7 months after radiotherapy. In multivariate analysis, pericardial V30 >41.6%, age >66 years, body mass index (BMI) >19 and diabetes mellitus (DM) were significant predictors of developing PCE. Conclusion: The present study suggests that higher pericardial V30, advanced age, high BMI and DM are risk factors for developing PCE.

Original languageEnglish
Pages (from-to)7389-7393
Number of pages5
JournalAnticancer research
Volume34
Issue number12
Publication statusPublished - Dec 1 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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