Abstract
Aim: We investigated clinical and dosimetric factors influencing the risk of developing pericardial effusion (PCE) in patients with Stage I esophageal cancer undergoing definitive chemoradiotherapy. Patients and Methods: Sixtynine patients with Stage I esophageal cancer who underwent definitive chemoradiotherapy were retrospectively analyzed. Treatment comprised of three-dimensional conformal radiotherapy (60 Gy in 30 fractions) with concurrent chemotherapy. Clinical and dosimetric factors associated with PCE development were analyzed. Results: The median follow-up was 37 months (range=8-111 months); the crude PCE incidence rate was 52.2%. Grade 2 and 3 incidence rate was 47.8% and 4.3%, respectively. The median time to PCE onset was 5.7 months after radiotherapy. In multivariate analysis, pericardial V30 >41.6%, age >66 years, body mass index (BMI) >19 and diabetes mellitus (DM) were significant predictors of developing PCE. Conclusion: The present study suggests that higher pericardial V30, advanced age, high BMI and DM are risk factors for developing PCE.
| Original language | English |
|---|---|
| Pages (from-to) | 7389-7393 |
| Number of pages | 5 |
| Journal | Anticancer Research |
| Volume | 34 |
| Issue number | 12 |
| Publication status | Published - Jan 1 2014 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Cancer Research
- Oncology
- Medicine(all)
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Risk factors for pericardial effusion in patients with stage i esophageal cancer treated with chemoradiotherapy. / Tamari, Keisuke; Isohashi, Fumiaki; Akino, Yuichi; Suzuki, Osamu; Seo, Yuji; Yoshioka, Yasuo; Hayashi, Yoshito; Nishida, Tsutomu; Takehara, Tetsuo; Mori, Masaki; Doki, Yuichiro; Ogawa, Kazuhiko.
In: Anticancer Research, Vol. 34, No. 12, 01.01.2014, p. 7389-7393.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk factors for pericardial effusion in patients with stage i esophageal cancer treated with chemoradiotherapy
AU - Tamari, Keisuke
AU - Isohashi, Fumiaki
AU - Akino, Yuichi
AU - Suzuki, Osamu
AU - Seo, Yuji
AU - Yoshioka, Yasuo
AU - Hayashi, Yoshito
AU - Nishida, Tsutomu
AU - Takehara, Tetsuo
AU - Mori, Masaki
AU - Doki, Yuichiro
AU - Ogawa, Kazuhiko
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Aim: We investigated clinical and dosimetric factors influencing the risk of developing pericardial effusion (PCE) in patients with Stage I esophageal cancer undergoing definitive chemoradiotherapy. Patients and Methods: Sixtynine patients with Stage I esophageal cancer who underwent definitive chemoradiotherapy were retrospectively analyzed. Treatment comprised of three-dimensional conformal radiotherapy (60 Gy in 30 fractions) with concurrent chemotherapy. Clinical and dosimetric factors associated with PCE development were analyzed. Results: The median follow-up was 37 months (range=8-111 months); the crude PCE incidence rate was 52.2%. Grade 2 and 3 incidence rate was 47.8% and 4.3%, respectively. The median time to PCE onset was 5.7 months after radiotherapy. In multivariate analysis, pericardial V30 >41.6%, age >66 years, body mass index (BMI) >19 and diabetes mellitus (DM) were significant predictors of developing PCE. Conclusion: The present study suggests that higher pericardial V30, advanced age, high BMI and DM are risk factors for developing PCE.
AB - Aim: We investigated clinical and dosimetric factors influencing the risk of developing pericardial effusion (PCE) in patients with Stage I esophageal cancer undergoing definitive chemoradiotherapy. Patients and Methods: Sixtynine patients with Stage I esophageal cancer who underwent definitive chemoradiotherapy were retrospectively analyzed. Treatment comprised of three-dimensional conformal radiotherapy (60 Gy in 30 fractions) with concurrent chemotherapy. Clinical and dosimetric factors associated with PCE development were analyzed. Results: The median follow-up was 37 months (range=8-111 months); the crude PCE incidence rate was 52.2%. Grade 2 and 3 incidence rate was 47.8% and 4.3%, respectively. The median time to PCE onset was 5.7 months after radiotherapy. In multivariate analysis, pericardial V30 >41.6%, age >66 years, body mass index (BMI) >19 and diabetes mellitus (DM) were significant predictors of developing PCE. Conclusion: The present study suggests that higher pericardial V30, advanced age, high BMI and DM are risk factors for developing PCE.
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UR - http://www.scopus.com/inward/citedby.url?scp=84918558524&partnerID=8YFLogxK
M3 - Article
C2 - 25503178
AN - SCOPUS:84918558524
VL - 34
SP - 7389
EP - 7393
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 12
ER -