Risk factors for portal venous thrombosis after splenectomy in patients with cirrhosis and portal hypertension

N. Kinjo, H. Kawanaka, Tomohiko Akahoshi, M. Tomikawa, Nami Yamashita, K. Konishi, K. Tanoue, K. Shirabe, Makoto Hashizume, Yoshihiko Maehara

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Background: Portal venous thrombosis (PVT) is a potentially fatal complication following splenectomy. Its mechanisms and risk factors are poorly understood, especially in patients with cirrhosis and portal hypertension. This study investigated risk factors for PVT following splenectomy in such patients. Methods: All consecutive patients with cirrhosis who underwent splenectomy in Kyushu University Hospital between 1998 and 2004 were included in this retrospective study. They were divided into two groups based on the presence or absence of postoperative PVT. Preoperative and operative factors were compared, and the relationships between formation of PVT and its independent variables were analysed. In some cases, portal venous flow was measured before and after splenectomy using duplex Doppler ultrasonography. Results: PVT developed after surgery in 17 (24 per cent) of 70 patients studied. Multivariable analysis showed that increased splenic vein diameter and low white cell count were significant independent risk factors for PVT. Portal venous flow after splenectomy was greatly reduced in the PVT group, but not in patients without PVT. Conclusion: Large splenic vein diameter and low white cell count are independent risk factors for PVT after splenectomy in patients with cirrhosis and portal hypertension.

Original languageEnglish
Pages (from-to)910-916
Number of pages7
JournalBritish Journal of Surgery
Volume97
Issue number6
DOIs
Publication statusPublished - Jun 1 2010

Fingerprint

Portal Hypertension
Splenectomy
Venous Thrombosis
Fibrosis
Splenic Vein
Doppler Duplex Ultrasonography
Cell Count
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Risk factors for portal venous thrombosis after splenectomy in patients with cirrhosis and portal hypertension. / Kinjo, N.; Kawanaka, H.; Akahoshi, Tomohiko; Tomikawa, M.; Yamashita, Nami; Konishi, K.; Tanoue, K.; Shirabe, K.; Hashizume, Makoto; Maehara, Yoshihiko.

In: British Journal of Surgery, Vol. 97, No. 6, 01.06.2010, p. 910-916.

Research output: Contribution to journalArticle

Kinjo, N, Kawanaka, H, Akahoshi, T, Tomikawa, M, Yamashita, N, Konishi, K, Tanoue, K, Shirabe, K, Hashizume, M & Maehara, Y 2010, 'Risk factors for portal venous thrombosis after splenectomy in patients with cirrhosis and portal hypertension', British Journal of Surgery, vol. 97, no. 6, pp. 910-916. https://doi.org/10.1002/bjs.7002
Kinjo, N. ; Kawanaka, H. ; Akahoshi, Tomohiko ; Tomikawa, M. ; Yamashita, Nami ; Konishi, K. ; Tanoue, K. ; Shirabe, K. ; Hashizume, Makoto ; Maehara, Yoshihiko. / Risk factors for portal venous thrombosis after splenectomy in patients with cirrhosis and portal hypertension. In: British Journal of Surgery. 2010 ; Vol. 97, No. 6. pp. 910-916.
@article{fea9afb67f5b48d2b9b59b3f2eb89bbf,
title = "Risk factors for portal venous thrombosis after splenectomy in patients with cirrhosis and portal hypertension",
abstract = "Background: Portal venous thrombosis (PVT) is a potentially fatal complication following splenectomy. Its mechanisms and risk factors are poorly understood, especially in patients with cirrhosis and portal hypertension. This study investigated risk factors for PVT following splenectomy in such patients. Methods: All consecutive patients with cirrhosis who underwent splenectomy in Kyushu University Hospital between 1998 and 2004 were included in this retrospective study. They were divided into two groups based on the presence or absence of postoperative PVT. Preoperative and operative factors were compared, and the relationships between formation of PVT and its independent variables were analysed. In some cases, portal venous flow was measured before and after splenectomy using duplex Doppler ultrasonography. Results: PVT developed after surgery in 17 (24 per cent) of 70 patients studied. Multivariable analysis showed that increased splenic vein diameter and low white cell count were significant independent risk factors for PVT. Portal venous flow after splenectomy was greatly reduced in the PVT group, but not in patients without PVT. Conclusion: Large splenic vein diameter and low white cell count are independent risk factors for PVT after splenectomy in patients with cirrhosis and portal hypertension.",
author = "N. Kinjo and H. Kawanaka and Tomohiko Akahoshi and M. Tomikawa and Nami Yamashita and K. Konishi and K. Tanoue and K. Shirabe and Makoto Hashizume and Yoshihiko Maehara",
year = "2010",
month = "6",
day = "1",
doi = "10.1002/bjs.7002",
language = "English",
volume = "97",
pages = "910--916",
journal = "British Journal of Surgery",
issn = "0007-1323",
publisher = "John Wiley and Sons Ltd",
number = "6",

}

TY - JOUR

T1 - Risk factors for portal venous thrombosis after splenectomy in patients with cirrhosis and portal hypertension

AU - Kinjo, N.

AU - Kawanaka, H.

AU - Akahoshi, Tomohiko

AU - Tomikawa, M.

AU - Yamashita, Nami

AU - Konishi, K.

AU - Tanoue, K.

AU - Shirabe, K.

AU - Hashizume, Makoto

AU - Maehara, Yoshihiko

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Background: Portal venous thrombosis (PVT) is a potentially fatal complication following splenectomy. Its mechanisms and risk factors are poorly understood, especially in patients with cirrhosis and portal hypertension. This study investigated risk factors for PVT following splenectomy in such patients. Methods: All consecutive patients with cirrhosis who underwent splenectomy in Kyushu University Hospital between 1998 and 2004 were included in this retrospective study. They were divided into two groups based on the presence or absence of postoperative PVT. Preoperative and operative factors were compared, and the relationships between formation of PVT and its independent variables were analysed. In some cases, portal venous flow was measured before and after splenectomy using duplex Doppler ultrasonography. Results: PVT developed after surgery in 17 (24 per cent) of 70 patients studied. Multivariable analysis showed that increased splenic vein diameter and low white cell count were significant independent risk factors for PVT. Portal venous flow after splenectomy was greatly reduced in the PVT group, but not in patients without PVT. Conclusion: Large splenic vein diameter and low white cell count are independent risk factors for PVT after splenectomy in patients with cirrhosis and portal hypertension.

AB - Background: Portal venous thrombosis (PVT) is a potentially fatal complication following splenectomy. Its mechanisms and risk factors are poorly understood, especially in patients with cirrhosis and portal hypertension. This study investigated risk factors for PVT following splenectomy in such patients. Methods: All consecutive patients with cirrhosis who underwent splenectomy in Kyushu University Hospital between 1998 and 2004 were included in this retrospective study. They were divided into two groups based on the presence or absence of postoperative PVT. Preoperative and operative factors were compared, and the relationships between formation of PVT and its independent variables were analysed. In some cases, portal venous flow was measured before and after splenectomy using duplex Doppler ultrasonography. Results: PVT developed after surgery in 17 (24 per cent) of 70 patients studied. Multivariable analysis showed that increased splenic vein diameter and low white cell count were significant independent risk factors for PVT. Portal venous flow after splenectomy was greatly reduced in the PVT group, but not in patients without PVT. Conclusion: Large splenic vein diameter and low white cell count are independent risk factors for PVT after splenectomy in patients with cirrhosis and portal hypertension.

UR - http://www.scopus.com/inward/record.url?scp=77952767367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952767367&partnerID=8YFLogxK

U2 - 10.1002/bjs.7002

DO - 10.1002/bjs.7002

M3 - Article

C2 - 20474001

AN - SCOPUS:77952767367

VL - 97

SP - 910

EP - 916

JO - British Journal of Surgery

JF - British Journal of Surgery

SN - 0007-1323

IS - 6

ER -