Risk factors for posterior subcapsular cataract in retinitis pigmentosa

Kohta Fujiwara, Yasuhiro Ikeda, Yusuke Murakami, Jun Funatsu, Shunji Nakatake, Takashi Tachibana, Noriko Yoshida, Shintaro Nakao, Toshio Hisatomi, Shigeo Yoshida, Takeshi Yoshitomi, Tatsuro Ishibashi, Koh Hei Sonoda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

PURPOSE. Posterior subcapsular cataract (PSC) is a frequent complication in patients with retinitis pigmentosa (RP). The risk factors for PSC formation in RP are largely unknown. The purpose of this study was to investigate the risk factors for PSC. METHODS. We retrospectively studied a total of 322 eyes of 173 patients who were diagnosed with typical RP. We considered the following possible risk factors for PSC: age, sex, hypertension, diabetes mellitus, high myopia, asthma, history of steroid intake, and aqueous flare. Aqueous flare values were measured consecutively in 2012 and 2013 using a laser flare cell meter. The lens including PSC was examined with a slit lamp after dilation with tropicamide 1% and phenylephrine 2.5%. RESULTS. The geometric mean values of aqueous flare and mean values of visual acuity were significantly higher for the RP patients with PSC compared to those without PSC (P = 0.0003, P = 0.0004, respectively). When the aqueous flare values were assessed continuously, each 1-log-transformed increase in flare levels was associated with an elevation of the likelihood of having PSC after multivariable adjustment (odds ratio: 1.71; 95% confidence interval: 1.05-2.77). There were no significant associations of the other possible risk factors with PSC. CONCLUSIONS. Our analysis demonstrated that elevated aqueous flare is a significant risk factor for PSC formation. This result might provide insights into the association of inflammation and the pathogenesis of PSC formation in RP.

Original languageEnglish
Pages (from-to)2534-2537
Number of pages4
JournalInvestigative Ophthalmology and Visual Science
Volume58
Issue number5
DOIs
Publication statusPublished - May 2017

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Retinitis Pigmentosa
Cataract
Aqueous Humor
Tropicamide
Social Adjustment
Myopia
Phenylephrine
Lenses
Visual Acuity
Dilatation
Diabetes Mellitus
Lasers
Asthma
Odds Ratio
Steroids
Confidence Intervals
Hypertension
Inflammation

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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Risk factors for posterior subcapsular cataract in retinitis pigmentosa. / Fujiwara, Kohta; Ikeda, Yasuhiro; Murakami, Yusuke; Funatsu, Jun; Nakatake, Shunji; Tachibana, Takashi; Yoshida, Noriko; Nakao, Shintaro; Hisatomi, Toshio; Yoshida, Shigeo; Yoshitomi, Takeshi; Ishibashi, Tatsuro; Sonoda, Koh Hei.

In: Investigative Ophthalmology and Visual Science, Vol. 58, No. 5, 05.2017, p. 2534-2537.

Research output: Contribution to journalArticle

Fujiwara, K, Ikeda, Y, Murakami, Y, Funatsu, J, Nakatake, S, Tachibana, T, Yoshida, N, Nakao, S, Hisatomi, T, Yoshida, S, Yoshitomi, T, Ishibashi, T & Sonoda, KH 2017, 'Risk factors for posterior subcapsular cataract in retinitis pigmentosa', Investigative Ophthalmology and Visual Science, vol. 58, no. 5, pp. 2534-2537. https://doi.org/10.1167/iovs.17-21612
Fujiwara, Kohta ; Ikeda, Yasuhiro ; Murakami, Yusuke ; Funatsu, Jun ; Nakatake, Shunji ; Tachibana, Takashi ; Yoshida, Noriko ; Nakao, Shintaro ; Hisatomi, Toshio ; Yoshida, Shigeo ; Yoshitomi, Takeshi ; Ishibashi, Tatsuro ; Sonoda, Koh Hei. / Risk factors for posterior subcapsular cataract in retinitis pigmentosa. In: Investigative Ophthalmology and Visual Science. 2017 ; Vol. 58, No. 5. pp. 2534-2537.
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AU - Fujiwara, Kohta

AU - Ikeda, Yasuhiro

AU - Murakami, Yusuke

AU - Funatsu, Jun

AU - Nakatake, Shunji

AU - Tachibana, Takashi

AU - Yoshida, Noriko

AU - Nakao, Shintaro

AU - Hisatomi, Toshio

AU - Yoshida, Shigeo

AU - Yoshitomi, Takeshi

AU - Ishibashi, Tatsuro

AU - Sonoda, Koh Hei

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N2 - PURPOSE. Posterior subcapsular cataract (PSC) is a frequent complication in patients with retinitis pigmentosa (RP). The risk factors for PSC formation in RP are largely unknown. The purpose of this study was to investigate the risk factors for PSC. METHODS. We retrospectively studied a total of 322 eyes of 173 patients who were diagnosed with typical RP. We considered the following possible risk factors for PSC: age, sex, hypertension, diabetes mellitus, high myopia, asthma, history of steroid intake, and aqueous flare. Aqueous flare values were measured consecutively in 2012 and 2013 using a laser flare cell meter. The lens including PSC was examined with a slit lamp after dilation with tropicamide 1% and phenylephrine 2.5%. RESULTS. The geometric mean values of aqueous flare and mean values of visual acuity were significantly higher for the RP patients with PSC compared to those without PSC (P = 0.0003, P = 0.0004, respectively). When the aqueous flare values were assessed continuously, each 1-log-transformed increase in flare levels was associated with an elevation of the likelihood of having PSC after multivariable adjustment (odds ratio: 1.71; 95% confidence interval: 1.05-2.77). There were no significant associations of the other possible risk factors with PSC. CONCLUSIONS. Our analysis demonstrated that elevated aqueous flare is a significant risk factor for PSC formation. This result might provide insights into the association of inflammation and the pathogenesis of PSC formation in RP.

AB - PURPOSE. Posterior subcapsular cataract (PSC) is a frequent complication in patients with retinitis pigmentosa (RP). The risk factors for PSC formation in RP are largely unknown. The purpose of this study was to investigate the risk factors for PSC. METHODS. We retrospectively studied a total of 322 eyes of 173 patients who were diagnosed with typical RP. We considered the following possible risk factors for PSC: age, sex, hypertension, diabetes mellitus, high myopia, asthma, history of steroid intake, and aqueous flare. Aqueous flare values were measured consecutively in 2012 and 2013 using a laser flare cell meter. The lens including PSC was examined with a slit lamp after dilation with tropicamide 1% and phenylephrine 2.5%. RESULTS. The geometric mean values of aqueous flare and mean values of visual acuity were significantly higher for the RP patients with PSC compared to those without PSC (P = 0.0003, P = 0.0004, respectively). When the aqueous flare values were assessed continuously, each 1-log-transformed increase in flare levels was associated with an elevation of the likelihood of having PSC after multivariable adjustment (odds ratio: 1.71; 95% confidence interval: 1.05-2.77). There were no significant associations of the other possible risk factors with PSC. CONCLUSIONS. Our analysis demonstrated that elevated aqueous flare is a significant risk factor for PSC formation. This result might provide insights into the association of inflammation and the pathogenesis of PSC formation in RP.

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