Risk factors for recurrence after curative resection of hepatitis C-related hepatocellular carcinoma in patients without postoperative interferon therapy

Yo ichi Yamashita, Ken Shirabe, Takeo Toshima, Eiji Tsuijita, Kazuki Takeishi, Norifumi Harimoto, Toru Ikegami, Tomoharu Yoshizumi, Tetsuo Ikeda, Yuji Soejima, Yoshihiko Maehara

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5 Citations (Scopus)

Abstract

Aim: Hepatitis C (HC)-related hepatocellular carcinoma (HCC; HC-HCC) is highly recurrent. Methods: From 1995-2007, 183 curative hepatic resections for primary solitary HC-HCC without postoperative interferon therapy were included in this study. The patients were divided into three groups: (i) 2cm or less (n=56); (ii) more than 2cm to less than 5cm (n=79); and (iii) 5cm or more (n=48). Independent risk factors for HC-HCC recurrence for each group were determined. Results: Independent risk factors for recurrence were aspartate aminotransferase or alanine aminotransferase (AST/ALT) of 80IU/L or more (hazard ratio [HR], 2.1; P=0.02) in patients with HCC of 2cm or less, des-γ-carboxy prothrombin of 100mAU/mL or more (HR, 2.5; P=0.02) and AST/ALT of 80IU/L or more (HR, 2.1; P=0.04) in patients with HCC of more than 2cm to less than 5cm, and the presence of macroscopic portal vein tumor thrombus (HR, 2.8; P=0.02) and AST/ALT of 80IU/L or more (HR, 2.1; P=0.04) in patients with HCC of 5cm or more. All 13 late recurrences of 1 year or more after hepatic resection (27.1%) in patients with HCC of 5cm or more were accompanied by AST/ALT of 80IU/L or more. Conclusion: AST/ALT of 80IU/L or more is an independent risk factor for the recurrence of primary solitary HC-HCC after curative resection irrespective of the primary HC-HCC size.

Original languageEnglish
Pages (from-to)1313-1320
Number of pages8
JournalHepatology Research
Volume43
Issue number12
DOIs
Publication statusPublished - Dec 2013

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases

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