Risk factors for the metabolic syndrome components of hypertension, diabetes mellitus, and dyslipidemia after living donor liver transplantation

Takeo Toshima, Tomoharu Yoshizumi, Shoichi Inokuchi, Yukiko Kosai-Fujimoto, Takeshi Kurihara, Shohei Yoshiya, Yohei Mano, Kazuki Takeishi, Shinji Itoh, Noboru Harada, Toru Ikegami, Yuji Soejima, Mototsugu Shimokawa, Yoshihiko Maehara, Masaki Mori

Research output: Contribution to journalArticle

Abstract

Background: Metabolic syndrome (MS) is the most common long-term complication after liver transplantation, and it has been increasing in incidence. The aim of this study was to clarify the risk factors for each MS component -hypertension, diabetes mellitus, and dyslipidemia-after living-donor liver transplantation (LDLT), including characteristics of living-donors. Methods: Data related to clinicopathological parameters including MS components in 461 consecutive patients who underwent LDLT were analyzed retrospectively. Results: Prevalence of all MS components (hypertension, diabetes mellitus, and dyslipidemia) increased from 9.3%, 16.5%, and 7.2% before LDLT to 44.9%, 45.3%, and 50.8% after LDLT, respectively. By multivariate logistic regression analysis, the three factors, cyclosporine use (OR 2.086, P = 0.001), recipient age (OR 1.036, P = 0.001), and BMI (OR 1.072, P = 0.026) were independent predictors for post-LDLT hypertension. Next, the three factors, male recipient (OR 2.471, P < 0.001), recipient age (OR 1.039, P = 0.002), and donor BMI (OR 1.124, P = 0.012) were independent for post-LDLT diabetes mellitus. The four factors, cyclosporine use (OR 2.015, P = 0.001), prolonged prednisolone use (OR 1.928, P = 0.002), recipient age (OR 1.019, P = 0.037), and GRWR (OR 0.316, P = 0.037) were independent for post-LDLT dyslipidemia as well. Conclusions: Not only recipient-related factors but also donor-related factors were independently associated with each targeted post-LDLT MS component.

Original languageEnglish
JournalHPB
DOIs
Publication statusAccepted/In press - Jan 1 2019

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Living Donors
Dyslipidemias
Liver Transplantation
Diabetes Mellitus
Hypertension
Independent Living
Cyclosporine
Tissue Donors
Prednisolone
Logistic Models
Regression Analysis
Incidence

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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Risk factors for the metabolic syndrome components of hypertension, diabetes mellitus, and dyslipidemia after living donor liver transplantation. / Toshima, Takeo; Yoshizumi, Tomoharu; Inokuchi, Shoichi; Kosai-Fujimoto, Yukiko; Kurihara, Takeshi; Yoshiya, Shohei; Mano, Yohei; Takeishi, Kazuki; Itoh, Shinji; Harada, Noboru; Ikegami, Toru; Soejima, Yuji; Shimokawa, Mototsugu; Maehara, Yoshihiko; Mori, Masaki.

In: HPB, 01.01.2019.

Research output: Contribution to journalArticle

Toshima, Takeo ; Yoshizumi, Tomoharu ; Inokuchi, Shoichi ; Kosai-Fujimoto, Yukiko ; Kurihara, Takeshi ; Yoshiya, Shohei ; Mano, Yohei ; Takeishi, Kazuki ; Itoh, Shinji ; Harada, Noboru ; Ikegami, Toru ; Soejima, Yuji ; Shimokawa, Mototsugu ; Maehara, Yoshihiko ; Mori, Masaki. / Risk factors for the metabolic syndrome components of hypertension, diabetes mellitus, and dyslipidemia after living donor liver transplantation. In: HPB. 2019.
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title = "Risk factors for the metabolic syndrome components of hypertension, diabetes mellitus, and dyslipidemia after living donor liver transplantation",
abstract = "Background: Metabolic syndrome (MS) is the most common long-term complication after liver transplantation, and it has been increasing in incidence. The aim of this study was to clarify the risk factors for each MS component -hypertension, diabetes mellitus, and dyslipidemia-after living-donor liver transplantation (LDLT), including characteristics of living-donors. Methods: Data related to clinicopathological parameters including MS components in 461 consecutive patients who underwent LDLT were analyzed retrospectively. Results: Prevalence of all MS components (hypertension, diabetes mellitus, and dyslipidemia) increased from 9.3{\%}, 16.5{\%}, and 7.2{\%} before LDLT to 44.9{\%}, 45.3{\%}, and 50.8{\%} after LDLT, respectively. By multivariate logistic regression analysis, the three factors, cyclosporine use (OR 2.086, P = 0.001), recipient age (OR 1.036, P = 0.001), and BMI (OR 1.072, P = 0.026) were independent predictors for post-LDLT hypertension. Next, the three factors, male recipient (OR 2.471, P < 0.001), recipient age (OR 1.039, P = 0.002), and donor BMI (OR 1.124, P = 0.012) were independent for post-LDLT diabetes mellitus. The four factors, cyclosporine use (OR 2.015, P = 0.001), prolonged prednisolone use (OR 1.928, P = 0.002), recipient age (OR 1.019, P = 0.037), and GRWR (OR 0.316, P = 0.037) were independent for post-LDLT dyslipidemia as well. Conclusions: Not only recipient-related factors but also donor-related factors were independently associated with each targeted post-LDLT MS component.",
author = "Takeo Toshima and Tomoharu Yoshizumi and Shoichi Inokuchi and Yukiko Kosai-Fujimoto and Takeshi Kurihara and Shohei Yoshiya and Yohei Mano and Kazuki Takeishi and Shinji Itoh and Noboru Harada and Toru Ikegami and Yuji Soejima and Mototsugu Shimokawa and Yoshihiko Maehara and Masaki Mori",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.hpb.2019.08.008",
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TY - JOUR

T1 - Risk factors for the metabolic syndrome components of hypertension, diabetes mellitus, and dyslipidemia after living donor liver transplantation

AU - Toshima, Takeo

AU - Yoshizumi, Tomoharu

AU - Inokuchi, Shoichi

AU - Kosai-Fujimoto, Yukiko

AU - Kurihara, Takeshi

AU - Yoshiya, Shohei

AU - Mano, Yohei

AU - Takeishi, Kazuki

AU - Itoh, Shinji

AU - Harada, Noboru

AU - Ikegami, Toru

AU - Soejima, Yuji

AU - Shimokawa, Mototsugu

AU - Maehara, Yoshihiko

AU - Mori, Masaki

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Metabolic syndrome (MS) is the most common long-term complication after liver transplantation, and it has been increasing in incidence. The aim of this study was to clarify the risk factors for each MS component -hypertension, diabetes mellitus, and dyslipidemia-after living-donor liver transplantation (LDLT), including characteristics of living-donors. Methods: Data related to clinicopathological parameters including MS components in 461 consecutive patients who underwent LDLT were analyzed retrospectively. Results: Prevalence of all MS components (hypertension, diabetes mellitus, and dyslipidemia) increased from 9.3%, 16.5%, and 7.2% before LDLT to 44.9%, 45.3%, and 50.8% after LDLT, respectively. By multivariate logistic regression analysis, the three factors, cyclosporine use (OR 2.086, P = 0.001), recipient age (OR 1.036, P = 0.001), and BMI (OR 1.072, P = 0.026) were independent predictors for post-LDLT hypertension. Next, the three factors, male recipient (OR 2.471, P < 0.001), recipient age (OR 1.039, P = 0.002), and donor BMI (OR 1.124, P = 0.012) were independent for post-LDLT diabetes mellitus. The four factors, cyclosporine use (OR 2.015, P = 0.001), prolonged prednisolone use (OR 1.928, P = 0.002), recipient age (OR 1.019, P = 0.037), and GRWR (OR 0.316, P = 0.037) were independent for post-LDLT dyslipidemia as well. Conclusions: Not only recipient-related factors but also donor-related factors were independently associated with each targeted post-LDLT MS component.

AB - Background: Metabolic syndrome (MS) is the most common long-term complication after liver transplantation, and it has been increasing in incidence. The aim of this study was to clarify the risk factors for each MS component -hypertension, diabetes mellitus, and dyslipidemia-after living-donor liver transplantation (LDLT), including characteristics of living-donors. Methods: Data related to clinicopathological parameters including MS components in 461 consecutive patients who underwent LDLT were analyzed retrospectively. Results: Prevalence of all MS components (hypertension, diabetes mellitus, and dyslipidemia) increased from 9.3%, 16.5%, and 7.2% before LDLT to 44.9%, 45.3%, and 50.8% after LDLT, respectively. By multivariate logistic regression analysis, the three factors, cyclosporine use (OR 2.086, P = 0.001), recipient age (OR 1.036, P = 0.001), and BMI (OR 1.072, P = 0.026) were independent predictors for post-LDLT hypertension. Next, the three factors, male recipient (OR 2.471, P < 0.001), recipient age (OR 1.039, P = 0.002), and donor BMI (OR 1.124, P = 0.012) were independent for post-LDLT diabetes mellitus. The four factors, cyclosporine use (OR 2.015, P = 0.001), prolonged prednisolone use (OR 1.928, P = 0.002), recipient age (OR 1.019, P = 0.037), and GRWR (OR 0.316, P = 0.037) were independent for post-LDLT dyslipidemia as well. Conclusions: Not only recipient-related factors but also donor-related factors were independently associated with each targeted post-LDLT MS component.

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U2 - 10.1016/j.hpb.2019.08.008

DO - 10.1016/j.hpb.2019.08.008

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JO - HPB

JF - HPB

SN - 1365-182X

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