Risk Factors Related to Liver Metastasis in Colorectal Carcinoma: A Multivariate Analysis of Clinicopathologic and Immunohistochemical Variables

Eishi Nagai, Takashi Yao, Maki Sakamoto, Kouhei Akazawa, Takashi Utsunomiya, Masazumi Tsuneyoshi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Specimens from 48 consecutive patients undergoing surgery for colorectal carcinoma and having synchronous or metachronous liver metastases (Group 1) and those from 52 consecutive patients who had no evidence of hepatic metastases within at least 5 year after colorectal resection (Group 2) were selected and compared using a multiple logistic regression analysis. A multivariate analysis using a stepwise logistic regression revealed six independent risk factors significantly related to hepatic metastases. In addition, the following logistic regression model was obtained from this analysis. P = exp a/(l+exp a): a = 3.524CSM‐V) + 2.731(Ex‐V) + 2.718CE/M) + 2.562(Lo) + 1.858(p53) + 1.941 (HIR)‐4.397, where P is the probability of hepatic metastasis given six independent risk factors (E/M, Ex/M ratio; Lo, location; HIR, host inflammatory cell reaction). When the estimated probability “P” in the above logistic regression model is more than 0.55 after an examination of surgical specimens, we must consider adjuvant chemotherapy and closely monitor the patient to ensure early detection of hepatic metastases.

Original languageEnglish
Pages (from-to)1280-1287
Number of pages8
JournalJapanese Journal of Cancer Research
Volume85
Issue number12
DOIs
Publication statusPublished - Dec 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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