Risk Factors Related to Liver Metastasis in Colorectal Carcinoma: A Multivariate Analysis of Clinicopathologic and Immunohistochemical Variables

Eishi Nagai, Takashi Yao, Maki Sakamoto, Kouhei Akazawa, Takashi Utsunomiya, Masazumi Tsuneyoshi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Specimens from 48 consecutive patients undergoing surgery for colorectal carcinoma and having synchronous or metachronous liver metastases (Group 1) and those from 52 consecutive patients who had no evidence of hepatic metastases within at least 5 year after colorectal resection (Group 2) were selected and compared using a multiple logistic regression analysis. A multivariate analysis using a stepwise logistic regression revealed six independent risk factors significantly related to hepatic metastases. In addition, the following logistic regression model was obtained from this analysis. P = exp a/(l+exp a): a = 3.524CSM‐V) + 2.731(Ex‐V) + 2.718CE/M) + 2.562(Lo) + 1.858(p53) + 1.941 (HIR)‐4.397, where P is the probability of hepatic metastasis given six independent risk factors (E/M, Ex/M ratio; Lo, location; HIR, host inflammatory cell reaction). When the estimated probability “P” in the above logistic regression model is more than 0.55 after an examination of surgical specimens, we must consider adjuvant chemotherapy and closely monitor the patient to ensure early detection of hepatic metastases.

Original languageEnglish
Pages (from-to)1280-1287
Number of pages8
JournalJapanese Journal of Cancer Research
Volume85
Issue number12
DOIs
Publication statusPublished - Dec 1994

Fingerprint

Colorectal Neoplasms
Multivariate Analysis
Logistic Models
Neoplasm Metastasis
Liver
Adjuvant Chemotherapy
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Risk Factors Related to Liver Metastasis in Colorectal Carcinoma : A Multivariate Analysis of Clinicopathologic and Immunohistochemical Variables. / Nagai, Eishi; Yao, Takashi; Sakamoto, Maki; Akazawa, Kouhei; Utsunomiya, Takashi; Tsuneyoshi, Masazumi.

In: Japanese Journal of Cancer Research, Vol. 85, No. 12, 12.1994, p. 1280-1287.

Research output: Contribution to journalArticle

Nagai, Eishi ; Yao, Takashi ; Sakamoto, Maki ; Akazawa, Kouhei ; Utsunomiya, Takashi ; Tsuneyoshi, Masazumi. / Risk Factors Related to Liver Metastasis in Colorectal Carcinoma : A Multivariate Analysis of Clinicopathologic and Immunohistochemical Variables. In: Japanese Journal of Cancer Research. 1994 ; Vol. 85, No. 12. pp. 1280-1287.
@article{55027eb2699a45418e9b104bbecac111,
title = "Risk Factors Related to Liver Metastasis in Colorectal Carcinoma: A Multivariate Analysis of Clinicopathologic and Immunohistochemical Variables",
abstract = "Specimens from 48 consecutive patients undergoing surgery for colorectal carcinoma and having synchronous or metachronous liver metastases (Group 1) and those from 52 consecutive patients who had no evidence of hepatic metastases within at least 5 year after colorectal resection (Group 2) were selected and compared using a multiple logistic regression analysis. A multivariate analysis using a stepwise logistic regression revealed six independent risk factors significantly related to hepatic metastases. In addition, the following logistic regression model was obtained from this analysis. P = exp a/(l+exp a): a = 3.524CSM‐V) + 2.731(Ex‐V) + 2.718CE/M) + 2.562(Lo) + 1.858(p53) + 1.941 (HIR)‐4.397, where P is the probability of hepatic metastasis given six independent risk factors (E/M, Ex/M ratio; Lo, location; HIR, host inflammatory cell reaction). When the estimated probability “P” in the above logistic regression model is more than 0.55 after an examination of surgical specimens, we must consider adjuvant chemotherapy and closely monitor the patient to ensure early detection of hepatic metastases.",
author = "Eishi Nagai and Takashi Yao and Maki Sakamoto and Kouhei Akazawa and Takashi Utsunomiya and Masazumi Tsuneyoshi",
year = "1994",
month = "12",
doi = "10.1111/j.1349-7006.1994.tb02941.x",
language = "English",
volume = "85",
pages = "1280--1287",
journal = "Cancer Science",
issn = "1347-9032",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Risk Factors Related to Liver Metastasis in Colorectal Carcinoma

T2 - A Multivariate Analysis of Clinicopathologic and Immunohistochemical Variables

AU - Nagai, Eishi

AU - Yao, Takashi

AU - Sakamoto, Maki

AU - Akazawa, Kouhei

AU - Utsunomiya, Takashi

AU - Tsuneyoshi, Masazumi

PY - 1994/12

Y1 - 1994/12

N2 - Specimens from 48 consecutive patients undergoing surgery for colorectal carcinoma and having synchronous or metachronous liver metastases (Group 1) and those from 52 consecutive patients who had no evidence of hepatic metastases within at least 5 year after colorectal resection (Group 2) were selected and compared using a multiple logistic regression analysis. A multivariate analysis using a stepwise logistic regression revealed six independent risk factors significantly related to hepatic metastases. In addition, the following logistic regression model was obtained from this analysis. P = exp a/(l+exp a): a = 3.524CSM‐V) + 2.731(Ex‐V) + 2.718CE/M) + 2.562(Lo) + 1.858(p53) + 1.941 (HIR)‐4.397, where P is the probability of hepatic metastasis given six independent risk factors (E/M, Ex/M ratio; Lo, location; HIR, host inflammatory cell reaction). When the estimated probability “P” in the above logistic regression model is more than 0.55 after an examination of surgical specimens, we must consider adjuvant chemotherapy and closely monitor the patient to ensure early detection of hepatic metastases.

AB - Specimens from 48 consecutive patients undergoing surgery for colorectal carcinoma and having synchronous or metachronous liver metastases (Group 1) and those from 52 consecutive patients who had no evidence of hepatic metastases within at least 5 year after colorectal resection (Group 2) were selected and compared using a multiple logistic regression analysis. A multivariate analysis using a stepwise logistic regression revealed six independent risk factors significantly related to hepatic metastases. In addition, the following logistic regression model was obtained from this analysis. P = exp a/(l+exp a): a = 3.524CSM‐V) + 2.731(Ex‐V) + 2.718CE/M) + 2.562(Lo) + 1.858(p53) + 1.941 (HIR)‐4.397, where P is the probability of hepatic metastasis given six independent risk factors (E/M, Ex/M ratio; Lo, location; HIR, host inflammatory cell reaction). When the estimated probability “P” in the above logistic regression model is more than 0.55 after an examination of surgical specimens, we must consider adjuvant chemotherapy and closely monitor the patient to ensure early detection of hepatic metastases.

UR - http://www.scopus.com/inward/record.url?scp=0028580521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028580521&partnerID=8YFLogxK

U2 - 10.1111/j.1349-7006.1994.tb02941.x

DO - 10.1111/j.1349-7006.1994.tb02941.x

M3 - Article

C2 - 7531682

AN - SCOPUS:0028580521

VL - 85

SP - 1280

EP - 1287

JO - Cancer Science

JF - Cancer Science

SN - 1347-9032

IS - 12

ER -