Risk stratification for congenital diaphragmatic hernia by factors within 24 h after birth

The Japanese Congenital Diaphragmatic Hernia Study Group

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To establish a simple risk stratification system for patients with congenital diaphragmatic hernia (CDH) based on postnatal information within 24 h after birth. Study Design: A multi-institutional retrospective cohort study was conducted including 348 neonates who had isolated CDH born between 2006 and 2010. Based on the two most powerful variables for 90-day survival selected by multivariate analyses, a risk stratification system was established. Results: Multiple logistic regression analysis identified two adverse prognostic factors: an Apgar score at 1 min (Ap1) of 0-4 (odds ratio (OR) 3.3, P=0.004), and a best oxygenation index (OI) ≥ 3/48.0 (OR 11.4, P<0.001). Based on a combinations of these two factors, patients were classified into three risk categories. The 90-day survival rates in categories 1-3 were 100, 88 and 52%, respectively (P<0.001). Conclusion: Our simple risk stratification system based on Ap1 and best OI was capable of predicting mortality well.

Original languageEnglish
Pages (from-to)805-808
Number of pages4
JournalJournal of Perinatology
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

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Parturition
Odds Ratio
Apgar Score
Cohort Studies
Multivariate Analysis
Survival Rate
Retrospective Studies
Logistic Models
Regression Analysis
Newborn Infant
Survival
Mortality
Congenital Diaphragmatic Hernias

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Risk stratification for congenital diaphragmatic hernia by factors within 24 h after birth. / The Japanese Congenital Diaphragmatic Hernia Study Group.

In: Journal of Perinatology, Vol. 37, No. 7, 01.07.2017, p. 805-808.

Research output: Contribution to journalArticle

The Japanese Congenital Diaphragmatic Hernia Study Group 2017, 'Risk stratification for congenital diaphragmatic hernia by factors within 24 h after birth', Journal of Perinatology, vol. 37, no. 7, pp. 805-808. https://doi.org/10.1038/jp.2017.11
The Japanese Congenital Diaphragmatic Hernia Study Group. / Risk stratification for congenital diaphragmatic hernia by factors within 24 h after birth. In: Journal of Perinatology. 2017 ; Vol. 37, No. 7. pp. 805-808.
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AU - Takahashi, S.

AU - Hayakawa, M.

AU - Okuyama, H.

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AU - Taguchi, T.

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