Rituximab for the treatment of corticosteroid-refractory chronic graft-versus-host disease

Takanori Teshima, Koji Nagafuji, Hideho Henzan, Koichi Miyamura, Ken Takase, Michihiro Hidaka, Toshihiro Miyamoto, Katsuto Takenaka, Koichi Akashi, Mine Harada

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Abstract

We prospectively evaluated the safety and efficacy of the anti-CD20 chimeric monoclonal antibody rituximab for the treatment of corticosteroid- refractory chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. Seven patients were treated with 375 mg/m2 rituximab weekly for 4 consecutive weeks. Rituximab was well tolerated with no severe toxicity observed during treatment. At 1 year, 3 patients showed a partial response to rituximab therapy, 3 had stable disease, and 1 had progressive disease. Rituximab allowed a reduction in the dose of steroids in 4 patients. Responsive manifestations included mild to moderate skin and oral lesions, and immune hemolytic anemia, and thrombocytopenia. Severe manifestations involving the skin, fascia, and eye did not respond to treatment. These observations suggest that rituximab therapy may be effective for select patients with corticosteroid-refractory chronic GVHD that is not advanced.

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalInternational journal of hematology
Volume90
Issue number2
DOIs
Publication statusPublished - Sep 1 2009

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All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Teshima, T., Nagafuji, K., Henzan, H., Miyamura, K., Takase, K., Hidaka, M., ... Harada, M. (2009). Rituximab for the treatment of corticosteroid-refractory chronic graft-versus-host disease. International journal of hematology, 90(2), 253-260. https://doi.org/10.1007/s12185-009-0370-x