TY - JOUR
T1 - Robust Ionic Current Sensor for Bacterial Cell Size Detection
AU - Yasaki, Hirotoshi
AU - Shimada, Taisuke
AU - Yasui, Takao
AU - Yanagida, Takeshi
AU - Kaji, Noritada
AU - Kanai, Masaki
AU - Nagashima, Kazuki
AU - Kawai, Tomoji
AU - Baba, Yoshinobu
N1 - Funding Information:
This research was supported by Grants-in-Aid for JSPS Research Fellow (15J03490, 17J05751), PREST (JPMJPR151B, JPMJPR16F4) JST, the JSPS Grant-in-Aid for Young Scientists (A) 17H04803, the ImPACT Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), and the JSPS Grant-in-Aid for Scientific Research (A) 16H02091.
Funding Information:
This research was supported by Grants-in-Aid for JSPS Research Fellow (15J03490, 17J05751), PREST (JPMJPR151B, JPMJPR16F4), JST, the JSPS Grant-in-Aid for Young Scientists (A) 17H04803, the ImPACT Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), and the JSPS Grant-in-Aid for Scientific Research (A) 16H02091.
Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/3/23
Y1 - 2018/3/23
N2 - Ionic current sensing methods are useful tools for detecting sub- to several-micron scale particles such as bacteria. However, conventional commercially available ionic current sensing devices are not suitable for on-site measurement use because of inherent limitations on their robustness. Here, we proposed a portable robust ionic current sensor (Robust-ICS) using a bridge circuit that offers a high signal-to-noise (S/N) ratio by suppressing background current. Because the Robust-ICS can tolerate increased noise in current sensing, a simple, lightweight electromagnetic shield can be used and measurements under large electromagnetic noise conditions can be made. The weight of the device was lowered below 4 kg and outdoor particle detection measurements were completed successfully. Accuracy of size detection of Staphylococcus aureus (S. aureus) was equivalent to that obtained by SEM imaging.
AB - Ionic current sensing methods are useful tools for detecting sub- to several-micron scale particles such as bacteria. However, conventional commercially available ionic current sensing devices are not suitable for on-site measurement use because of inherent limitations on their robustness. Here, we proposed a portable robust ionic current sensor (Robust-ICS) using a bridge circuit that offers a high signal-to-noise (S/N) ratio by suppressing background current. Because the Robust-ICS can tolerate increased noise in current sensing, a simple, lightweight electromagnetic shield can be used and measurements under large electromagnetic noise conditions can be made. The weight of the device was lowered below 4 kg and outdoor particle detection measurements were completed successfully. Accuracy of size detection of Staphylococcus aureus (S. aureus) was equivalent to that obtained by SEM imaging.
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U2 - 10.1021/acssensors.8b00045
DO - 10.1021/acssensors.8b00045
M3 - Article
C2 - 29420015
AN - SCOPUS:85044400419
VL - 3
SP - 574
EP - 579
JO - ACS Sensors
JF - ACS Sensors
SN - 2379-3694
IS - 3
ER -