Robust Ionic Current Sensor for Bacterial Cell Size Detection

Hirotoshi Yasaki; Taisuke Shimada; Takao Yasui; Takeshi Yanagida; Noritada Kaji; Masaki Kanai; Kazuki Nagashima; Tomoji Kawai; Yoshinobu Baba

doi:10.1021/acssensors.8b00045

Robust Ionic Current Sensor for Bacterial Cell Size Detection

Hirotoshi Yasaki, Taisuke Shimada, Takao Yasui, Takeshi Yanagida, Noritada Kaji, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

Ionic current sensing methods are useful tools for detecting sub- to several-micron scale particles such as bacteria. However, conventional commercially available ionic current sensing devices are not suitable for on-site measurement use because of inherent limitations on their robustness. Here, we proposed a portable robust ionic current sensor (Robust-ICS) using a bridge circuit that offers a high signal-to-noise (S/N) ratio by suppressing background current. Because the Robust-ICS can tolerate increased noise in current sensing, a simple, lightweight electromagnetic shield can be used and measurements under large electromagnetic noise conditions can be made. The weight of the device was lowered below 4 kg and outdoor particle detection measurements were completed successfully. Accuracy of size detection of Staphylococcus aureus (S. aureus) was equivalent to that obtained by SEM imaging.

Original language	English
Pages (from-to)	574-579
Number of pages	6
Journal	ACS sensors
Volume	3
Issue number	3
DOIs	https://doi.org/10.1021/acssensors.8b00045
Publication status	Published - Mar 23 2018

All Science Journal Classification (ASJC) codes

Bioengineering
Instrumentation
Process Chemistry and Technology
Fluid Flow and Transfer Processes

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Yasaki, H., Shimada, T., Yasui, T., Yanagida, T., Kaji, N., Kanai, M., Nagashima, K., Kawai, T., & Baba, Y. (2018). Robust Ionic Current Sensor for Bacterial Cell Size Detection. ACS sensors, 3(3), 574-579. https://doi.org/10.1021/acssensors.8b00045

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abstract = "Ionic current sensing methods are useful tools for detecting sub- to several-micron scale particles such as bacteria. However, conventional commercially available ionic current sensing devices are not suitable for on-site measurement use because of inherent limitations on their robustness. Here, we proposed a portable robust ionic current sensor (Robust-ICS) using a bridge circuit that offers a high signal-to-noise (S/N) ratio by suppressing background current. Because the Robust-ICS can tolerate increased noise in current sensing, a simple, lightweight electromagnetic shield can be used and measurements under large electromagnetic noise conditions can be made. The weight of the device was lowered below 4 kg and outdoor particle detection measurements were completed successfully. Accuracy of size detection of Staphylococcus aureus (S. aureus) was equivalent to that obtained by SEM imaging.",

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AU - Yasaki, Hirotoshi

AU - Shimada, Taisuke

AU - Yasui, Takao

AU - Yanagida, Takeshi

AU - Kaji, Noritada

AU - Kanai, Masaki

AU - Nagashima, Kazuki

AU - Kawai, Tomoji

AU - Baba, Yoshinobu

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