Robust surface modification for protein separation chip using a film of a cellulose derivative

H. Okada, Noritada Kaji, M. Tokeshi, Y. Baba

Research output: Contribution to conferencePaper

Abstract

We developed a new surface modification method using poly(methyl methacrylate) (PMMA) with a film of a cellulose derivative to ensure the long-term stability of the modification. For electrophoretic protein separation using PMMA chips as well as other polymeric chips, protein adsorption is so inevitable that analytical errors (band broadening, low detection sensitivity) are unavoidable. However, our new method overcame these drawbacks of polymeric materials and provided much better analytical performances (higher theoretical plates and consecutive runs in a single channel) than other reported methods of surface modification.

Original languageEnglish
Pages251-253
Number of pages3
Publication statusPublished - Jan 1 2008
Externally publishedYes
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: Oct 12 2008Oct 16 2008

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
CountryUnited States
CitySan Diego, CA
Period10/12/0810/16/08

Fingerprint

Cellulose derivatives
Polymethyl Methacrylate
Polymethyl methacrylates
Surface treatment
Proteins
Adsorption
Polymers

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Okada, H., Kaji, N., Tokeshi, M., & Baba, Y. (2008). Robust surface modification for protein separation chip using a film of a cellulose derivative. 251-253. Paper presented at 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, United States.

Robust surface modification for protein separation chip using a film of a cellulose derivative. / Okada, H.; Kaji, Noritada; Tokeshi, M.; Baba, Y.

2008. 251-253 Paper presented at 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, United States.

Research output: Contribution to conferencePaper

Okada, H, Kaji, N, Tokeshi, M & Baba, Y 2008, 'Robust surface modification for protein separation chip using a film of a cellulose derivative' Paper presented at 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, United States, 10/12/08 - 10/16/08, pp. 251-253.
Okada H, Kaji N, Tokeshi M, Baba Y. Robust surface modification for protein separation chip using a film of a cellulose derivative. 2008. Paper presented at 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, United States.
Okada, H. ; Kaji, Noritada ; Tokeshi, M. ; Baba, Y. / Robust surface modification for protein separation chip using a film of a cellulose derivative. Paper presented at 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, United States.3 p.
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