Role of 5-HT1B receptors in entrainment disorder of Otsuka Long Evans Tokushima fatty (OLETF) rats

Takao Shimazoe, S. Nakamura, K. Kobayashi, S. Watanabe, K. Miyasaka, A. Kono, A. Funakoshi

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Abstract

The role of 5-HT1A and 5-HT1B receptors in entrainment function was studied in Otsuka Long Evans Tokushima fatty (OLETF) rats and control Long Evans Tokushima Otsuka (LETO) rats. Light-induced (100 lux, 30 min) Fos expression in the suprachiasmatic nucleus was studied. Light-induced Fos expression was significantly decreased in OLETF rats compared to that in LETO rats. The decrease of light-induced Fos expression in OLETF rats was significantly reversed by pretreatment with the 5-HT1B receptor antagonist, isamoltan (3 mg/kg, i.p.). Simultaneous administration of CGS12066B (5 mg/kg, i.p.), a 5-HT1B agonist, blocked the reversal effect of isamoltan on Fos expression. Fos expression was not changed in LETO rats by pretreatment with isamoltan (3 mg/kg, i.p.). The Fos expression in LETO and OLETF rats was significantly decreased by pretreatment with the 5-HT1A antagonist, WAY-100,635. Phase shifts in locomotor activity paralleled the Fos expression. Light-induced phase shifts of locomotor activity in OLETF rats were significantly smaller than those in LETO rats. The phase shifts were significantly increased by isamoltan (3 mg/kg, i.p.) in OLETF rats. These results suggest that 5-HT1B receptors are involved in the reduced entrainment function of OLETF rats.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalNeuroscience
Volume123
Issue number1
DOIs
Publication statusPublished - Jan 1 2004

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Inbred OLETF Rats
Receptor, Serotonin, 5-HT1B
Serotonin 5-HT1 Receptor Antagonists
Light
Locomotion
Serotonin 5-HT1 Receptor Agonists
Suprachiasmatic Nucleus

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Role of 5-HT1B receptors in entrainment disorder of Otsuka Long Evans Tokushima fatty (OLETF) rats. / Shimazoe, Takao; Nakamura, S.; Kobayashi, K.; Watanabe, S.; Miyasaka, K.; Kono, A.; Funakoshi, A.

In: Neuroscience, Vol. 123, No. 1, 01.01.2004, p. 201-205.

Research output: Contribution to journalArticle

Shimazoe, T, Nakamura, S, Kobayashi, K, Watanabe, S, Miyasaka, K, Kono, A & Funakoshi, A 2004, 'Role of 5-HT1B receptors in entrainment disorder of Otsuka Long Evans Tokushima fatty (OLETF) rats', Neuroscience, vol. 123, no. 1, pp. 201-205. https://doi.org/10.1016/j.neuroscience.2003.08.024
Shimazoe, Takao ; Nakamura, S. ; Kobayashi, K. ; Watanabe, S. ; Miyasaka, K. ; Kono, A. ; Funakoshi, A. / Role of 5-HT1B receptors in entrainment disorder of Otsuka Long Evans Tokushima fatty (OLETF) rats. In: Neuroscience. 2004 ; Vol. 123, No. 1. pp. 201-205.
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