Role of 5-hydroxytryptamine 2C receptors in marble-burying behavior in mice

Nobuaki Egashira, Ryoko Okuno, Atsunori Shirakawa, Masaki Nagao, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

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8 Citations (Scopus)

Abstract

We examined the role of 5-hydroxytryptamine 2C (5-HT 2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT 2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT 2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT 2C receptors play a role in marble-burying behavior in mice.

Original languageEnglish
Pages (from-to)376-379
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume35
Issue number3
DOIs
Publication statusPublished - Mar 1 2012

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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    Egashira, N., Okuno, R., Shirakawa, A., Nagao, M., Mishima, K., Iwasaki, K., Oishi, R., & Fujiwara, M. (2012). Role of 5-hydroxytryptamine 2C receptors in marble-burying behavior in mice. Biological and Pharmaceutical Bulletin, 35(3), 376-379. https://doi.org/10.1248/bpb.35.376