Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice

Nobuaki Egashira; Ryoko Okuno; Atsunori Shirakawa; Masaki Nagao; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Michihiro Fujiwara

doi:10.1248/bpb.35.376

Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice

Nobuaki Egashira, Ryoko Okuno, Atsunori Shirakawa, Masaki Nagao, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

We examined the role of 5-hydroxytryptamine2C (5-HT2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT2C receptors play a role in marble-burying behavior in mice.

Original language	English
Pages (from-to)	376-379
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	35
Issue number	3
DOIs	https://doi.org/10.1248/bpb.35.376
Publication status	Published - 2012

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title = "Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice",

abstract = "We examined the role of 5-hydroxytryptamine2C (5-HT2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT2C receptors play a role in marble-burying behavior in mice.",

author = "Nobuaki Egashira and Ryoko Okuno and Atsunori Shirakawa and Masaki Nagao and Kenichi Mishima and Katsunori Iwasaki and Ryozo Oishi and Michihiro Fujiwara",

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doi = "10.1248/bpb.35.376",

language = "English",

volume = "35",

pages = "376--379",

journal = "Biological and Pharmaceutical Bulletin",

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AU - Egashira, Nobuaki

AU - Okuno, Ryoko

AU - Shirakawa, Atsunori

AU - Nagao, Masaki

AU - Mishima, Kenichi

AU - Iwasaki, Katsunori

AU - Oishi, Ryozo

AU - Fujiwara, Michihiro

PY - 2012

Y1 - 2012

N2 - We examined the role of 5-hydroxytryptamine2C (5-HT2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT2C receptors play a role in marble-burying behavior in mice.

AB - We examined the role of 5-hydroxytryptamine2C (5-HT2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT2C receptors play a role in marble-burying behavior in mice.

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DO - 10.1248/bpb.35.376

M3 - Article

SN - 0918-6158

VL - 35

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EP - 379

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 3

ER -

Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice

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