Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice

Nobuaki Egashira, Ryoko Okuno, Atsunori Shirakawa, Masaki Nagao, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the role of 5-hydroxytryptamine<sub>2C</sub> (5-HT<sub>2C</sub>) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT<sub>2C</sub> agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT<sub>2C</sub> antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT<sub>2C</sub> receptors play a role in marble-burying behavior in mice.
Original languageEnglish
Pages (from-to)376-379
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume35
Issue number3
DOIs
Publication statusPublished - 2012

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