Role of aldosterone in left ventricular hypertrophy in hypertension

Kiyoshi Matsumura, Koji Fujii, Hideyuki Oniki, Masayo Oka, Mitsuo Iida

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Background: Aldosterone induces cardiac fibrosis in experimental animal models, but only limited information is available on the association between aldosterone and left ventricular (LV) hypertrophy in human beings. The aim of the present study was to determine the role of aldosterone in LV geometry and to investigate other types of target organ damage in hypertensive patients. Methods: A total of 25 patients with primary aldosteronism caused by Conn's adenoma, 29 patients with renovascular hypertension, and 29 patients with essential hypertension (EHT) were included in the present study. Echocardiographic examinations and 24-h ambulatory blood pressure (BP) monitoring were conducted in all subjects. Results: The mean 24-h systolic and diastolic BP in primary aldosteronism and renovascular hypertension were found to be comparable to those in EHT. However, LV mass index adjusted by age, sex, mean 24-h systolic BP, mean 24-h pulse rate, body mass index, and duration of hypertension was significantly increased in the patients with primary aldosteronism and renovascular hypertension compared with values in patients with EHT (150.2 ± 7.7, 142.3 ± 7.2, and 115.2 ± 7.2 g/m2, respectively). Hypertensive organ damages, such as proteinuria and hypertensive retinopathy, were more pronounced in the patients with renovascular hypertension; however, LV hypertrophy was especially exaggerated in patients with primary aldosteronism. Conclusions: These results indicate that aldosterone may induce LV hypertrophy in human beings as well as in experimental animals, and that angiotensin II and aldosterone may differentially participate in causing hypertensive target organ damage.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalAmerican Journal of Hypertension
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 1 2006

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Left Ventricular Hypertrophy
Aldosterone
Hypertension
Renovascular Hypertension
Hyperaldosteronism
Blood Pressure
Hypertensive Retinopathy
Adrenocortical Adenoma
Ambulatory Blood Pressure Monitoring
Proteinuria
Angiotensin II
Body Mass Index
Fibrosis
Animal Models
Heart Rate
Essential Hypertension

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Role of aldosterone in left ventricular hypertrophy in hypertension. / Matsumura, Kiyoshi; Fujii, Koji; Oniki, Hideyuki; Oka, Masayo; Iida, Mitsuo.

In: American Journal of Hypertension, Vol. 19, No. 1, 01.01.2006, p. 13-18.

Research output: Contribution to journalArticle

Matsumura, Kiyoshi ; Fujii, Koji ; Oniki, Hideyuki ; Oka, Masayo ; Iida, Mitsuo. / Role of aldosterone in left ventricular hypertrophy in hypertension. In: American Journal of Hypertension. 2006 ; Vol. 19, No. 1. pp. 13-18.
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