Role of asymmetric signals in left-right patterning in the mouse

Hiroshi Hamada, Chikara Meno, Yukio Saijoh, Hitoshi Adachi, Kenta Yashiro, Rui Sakuma, Hidetaka Shiratori

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Left-right asymmetric signaling molecules in mammals include three transforming growth factor β (TGFβ)-related factors, Nodal, Lefty1 and Lefty2. They are all expressed on the left half of developing mouse embryos. Nodal acts as a left-side determinant by transducing signals through Smad and FAST and by inducing Pitx2 expression on the left side. Lefty proteins are antagonists that inhibit Nodal signaling. There are positive and negative transcriptional regulatory loops between nodal and lefty2 genes. Thus, Nodal activates its own gene and lefty2. Lefty2 protein produced then inhibits Nodal signaling and terminates expression of both genes. This feedback mechanism can restrict the range and duration of Nodal signaling in developing embryos.

Original languageEnglish
Pages (from-to)324-327
Number of pages4
JournalAmerican Journal of Medical Genetics
Volume101
Issue number4
DOIs
Publication statusPublished - Jul 15 2001
Externally publishedYes

Fingerprint

Left-Right Determination Factors
Embryonic Structures
Transforming Growth Factors
Genes
Mammals
Gene Expression
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Hamada, H., Meno, C., Saijoh, Y., Adachi, H., Yashiro, K., Sakuma, R., & Shiratori, H. (2001). Role of asymmetric signals in left-right patterning in the mouse. American Journal of Medical Genetics, 101(4), 324-327. https://doi.org/10.1002/ajmg.1250

Role of asymmetric signals in left-right patterning in the mouse. / Hamada, Hiroshi; Meno, Chikara; Saijoh, Yukio; Adachi, Hitoshi; Yashiro, Kenta; Sakuma, Rui; Shiratori, Hidetaka.

In: American Journal of Medical Genetics, Vol. 101, No. 4, 15.07.2001, p. 324-327.

Research output: Contribution to journalArticle

Hamada, H, Meno, C, Saijoh, Y, Adachi, H, Yashiro, K, Sakuma, R & Shiratori, H 2001, 'Role of asymmetric signals in left-right patterning in the mouse', American Journal of Medical Genetics, vol. 101, no. 4, pp. 324-327. https://doi.org/10.1002/ajmg.1250
Hamada, Hiroshi ; Meno, Chikara ; Saijoh, Yukio ; Adachi, Hitoshi ; Yashiro, Kenta ; Sakuma, Rui ; Shiratori, Hidetaka. / Role of asymmetric signals in left-right patterning in the mouse. In: American Journal of Medical Genetics. 2001 ; Vol. 101, No. 4. pp. 324-327.
@article{36254c48d95741a2b494730fba351b8b,
title = "Role of asymmetric signals in left-right patterning in the mouse",
abstract = "Left-right asymmetric signaling molecules in mammals include three transforming growth factor β (TGFβ)-related factors, Nodal, Lefty1 and Lefty2. They are all expressed on the left half of developing mouse embryos. Nodal acts as a left-side determinant by transducing signals through Smad and FAST and by inducing Pitx2 expression on the left side. Lefty proteins are antagonists that inhibit Nodal signaling. There are positive and negative transcriptional regulatory loops between nodal and lefty2 genes. Thus, Nodal activates its own gene and lefty2. Lefty2 protein produced then inhibits Nodal signaling and terminates expression of both genes. This feedback mechanism can restrict the range and duration of Nodal signaling in developing embryos.",
author = "Hiroshi Hamada and Chikara Meno and Yukio Saijoh and Hitoshi Adachi and Kenta Yashiro and Rui Sakuma and Hidetaka Shiratori",
year = "2001",
month = "7",
day = "15",
doi = "10.1002/ajmg.1250",
language = "English",
volume = "101",
pages = "324--327",
journal = "American Journal of Medical Genetics, Part A",
issn = "1552-4825",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Role of asymmetric signals in left-right patterning in the mouse

AU - Hamada, Hiroshi

AU - Meno, Chikara

AU - Saijoh, Yukio

AU - Adachi, Hitoshi

AU - Yashiro, Kenta

AU - Sakuma, Rui

AU - Shiratori, Hidetaka

PY - 2001/7/15

Y1 - 2001/7/15

N2 - Left-right asymmetric signaling molecules in mammals include three transforming growth factor β (TGFβ)-related factors, Nodal, Lefty1 and Lefty2. They are all expressed on the left half of developing mouse embryos. Nodal acts as a left-side determinant by transducing signals through Smad and FAST and by inducing Pitx2 expression on the left side. Lefty proteins are antagonists that inhibit Nodal signaling. There are positive and negative transcriptional regulatory loops between nodal and lefty2 genes. Thus, Nodal activates its own gene and lefty2. Lefty2 protein produced then inhibits Nodal signaling and terminates expression of both genes. This feedback mechanism can restrict the range and duration of Nodal signaling in developing embryos.

AB - Left-right asymmetric signaling molecules in mammals include three transforming growth factor β (TGFβ)-related factors, Nodal, Lefty1 and Lefty2. They are all expressed on the left half of developing mouse embryos. Nodal acts as a left-side determinant by transducing signals through Smad and FAST and by inducing Pitx2 expression on the left side. Lefty proteins are antagonists that inhibit Nodal signaling. There are positive and negative transcriptional regulatory loops between nodal and lefty2 genes. Thus, Nodal activates its own gene and lefty2. Lefty2 protein produced then inhibits Nodal signaling and terminates expression of both genes. This feedback mechanism can restrict the range and duration of Nodal signaling in developing embryos.

UR - http://www.scopus.com/inward/record.url?scp=0035879552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035879552&partnerID=8YFLogxK

U2 - 10.1002/ajmg.1250

DO - 10.1002/ajmg.1250

M3 - Article

C2 - 11471154

AN - SCOPUS:0035879552

VL - 101

SP - 324

EP - 327

JO - American Journal of Medical Genetics, Part A

JF - American Journal of Medical Genetics, Part A

SN - 1552-4825

IS - 4

ER -