Role of CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory

Eiki Takahashi; Kimie Niimi; Chitoshi Itakura

doi:10.1016/j.bbr.2010.12.019

Role of CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory

Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Heterozygous rolling Nagoya (rol/+) mice with a Ca_V2.1α₁ mutation show normal Y-maze behavior. Intra-accumbens injection of N-methyl-d-aspartate (NMDA; 0-2.0μg/side) induced similar spontaneous alternations in wild-type and rol/+ mice; injections of NMDA receptor antagonist MK-801 (0.5μg/side) or Ca_V2.1 inhibitor levetiracetam (0.1μg/side) did not affect controls but decreased spatial cognition in rol/+ mice, suggesting that Ca_V2.1-mediated NMDA receptor signaling in the nucleus accumbens is involved in short-term spatial learning.

Original language	English
Pages (from-to)	353-356
Number of pages	4
Journal	Behavioural Brain Research
Volume	218
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2010.12.019
Publication status	Published - Apr 15 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Behavioral Neuroscience

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10.1016/j.bbr.2010.12.019

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title = "Role of CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory",

abstract = "Heterozygous rolling Nagoya (rol/+) mice with a CaV2.1α1 mutation show normal Y-maze behavior. Intra-accumbens injection of N-methyl-d-aspartate (NMDA; 0-2.0μg/side) induced similar spontaneous alternations in wild-type and rol/+ mice; injections of NMDA receptor antagonist MK-801 (0.5μg/side) or CaV2.1 inhibitor levetiracetam (0.1μg/side) did not affect controls but decreased spatial cognition in rol/+ mice, suggesting that CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens is involved in short-term spatial learning.",

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doi = "10.1016/j.bbr.2010.12.019",

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AU - Takahashi, Eiki

AU - Niimi, Kimie

AU - Itakura, Chitoshi

PY - 2011/4/15

Y1 - 2011/4/15

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AB - Heterozygous rolling Nagoya (rol/+) mice with a CaV2.1α1 mutation show normal Y-maze behavior. Intra-accumbens injection of N-methyl-d-aspartate (NMDA; 0-2.0μg/side) induced similar spontaneous alternations in wild-type and rol/+ mice; injections of NMDA receptor antagonist MK-801 (0.5μg/side) or CaV2.1 inhibitor levetiracetam (0.1μg/side) did not affect controls but decreased spatial cognition in rol/+ mice, suggesting that CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens is involved in short-term spatial learning.

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Role of CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory

Abstract

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