Role of CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory

Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Heterozygous rolling Nagoya (rol/+) mice with a CaV2.1α1 mutation show normal Y-maze behavior. Intra-accumbens injection of N-methyl-d-aspartate (NMDA; 0-2.0μg/side) induced similar spontaneous alternations in wild-type and rol/+ mice; injections of NMDA receptor antagonist MK-801 (0.5μg/side) or CaV2.1 inhibitor levetiracetam (0.1μg/side) did not affect controls but decreased spatial cognition in rol/+ mice, suggesting that CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens is involved in short-term spatial learning.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalBehavioural Brain Research
Volume218
Issue number2
DOIs
Publication statusPublished - Apr 15 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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