Abstract
Heterozygous rolling Nagoya (rol/+) mice with a CaV2.1α1 mutation show normal Y-maze behavior. Intra-accumbens injection of N-methyl-d-aspartate (NMDA; 0-2.0μg/side) induced similar spontaneous alternations in wild-type and rol/+ mice; injections of NMDA receptor antagonist MK-801 (0.5μg/side) or CaV2.1 inhibitor levetiracetam (0.1μg/side) did not affect controls but decreased spatial cognition in rol/+ mice, suggesting that CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens is involved in short-term spatial learning.
Original language | English |
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Pages (from-to) | 353-356 |
Number of pages | 4 |
Journal | Behavioural Brain Research |
Volume | 218 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 15 2011 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Behavioral Neuroscience