[Role of chronic inflammation in adipose tissue in the pathophysiology of obesity].

Takayoshi Suganami, Yoshihiro Ogawa

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Obesity may be viewed as a chronic low-grade inflammatory disease as well as a metabolic disease. Evidence has accumulated suggesting that chronic inflammation in adipose tissue leads to dramatic changes in number and cell type of stromal cells during the course of obesity, which is referred to as"adipose tissue remodeling". Among stromal cells, macrophages in obese adipose tissue are considered to be crucial for adipose tissue inflammation, which results in dysregulated adipocytokine production and ectopic fat accumulation. Understanding the molecular mechanism underlying adipose tissue inflammation would contribute to the identification of novel therapeutic strategies to prevent or treat obesity-induced metabolic derangements.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalUnknown Journal
Volume71
Issue number2
Publication statusPublished - Jan 1 2013
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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