Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells

Shigeru Sugiyama, Kazuhiko Nakabayashi, Iwai Baba, Takehiko Sasazuki, Senji Shirasawa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have previously found that epiregulin, a member of epidermal growth factor superfamily, is involved in proinflammatory cytokine production in bone marrow-derived macrophages. In this report, to further assess the role of epiregulin in innate immunity, we measured IL-6 production levels upon lipopolysaccharide and peptidoglycan stimulation in antigen presenting cells including macrophages and dendritic cells. Our analyses using epiregulin-deficient mice with mixed and inbred genetic backgrounds revealed that epiregulin deficiency results in the reduction of IL-6 production levels in both cell types upon peptidoglycan stimulation, and that the extent of this reduction is more evident under the BALB/c background compared with the C57BL/6J background. These results indicated that epiregulin may have a critical role in the regulation of peptidoglycan-mediated proinflammatory cytokine production in antigen presenting cells and innate immunity.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume337
Issue number1
DOIs
Publication statusPublished - Nov 11 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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