Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage

Kouji Kobiyama, Akira Kawashima, Nao Jounai, Fumihiko Takeshita, Ken J. Ishii, Tetsuhide Ito, Koichi Suzuki

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Histones are essential components of chromatin structure, and histone modification plays an important role in various cellular functions including transcription, gene silencing, and immunity. Histones also play distinct roles in extrachromosomal settings. Extrachromosomal histone H2B acts as a cytosolic sensor to detect double-stranded DNA (dsDNA) fragments derived from infectious agents or damaged cells to activate innate and acquired immune responses in various cell types. It also physically interacts with interferon (IFN)-β promoter stimulator 1 (IPS-1), an essential adaptor molecule that activates innate immunity, through COOH-terminal importin 9-related adaptor organizing histone H2B and IPS-1 (CIAO), resulting in a distinct signaling complex that induces dsDNA-induced type I IFN production. Such a molecular platform acts a a cellular sensor to recognize aberrant dsDNA in cases of viral infection and cell damage. This mechanism may also play roles in autoimmunity, transplantation rejection, gene-mediated vaccines, and other therapeutic applications.

Original languageEnglish
Article numberArticle 91
JournalFrontiers in Genetics
Volume4
Issue numberMAY
DOIs
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

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